Version history

{
  "kind": "infographic",
  "prompt": "VIP disinhibition effect sizes across studies",
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      {
        "n": null,
        "doi": "10.7554/elife.05558",
        "value": "1 (from abstract context)",
        "cite_key": "Fu2015",
        "n_definition": "varies - mice, neurons, or recordings",
        "scope_region": "varies by study",
        "scope_population": "VIP interneurons",
        "value_source_sentence": "In previous work, we have shown that locomotion dramatically enhances neural activity in the visual cortex (V1) of the mouse (Niell and Stryker, 2010), identified the cortical circuit responsible for this enhancement (Fu et al., 2014), and shown that locomotion also dramatically enhances adult plasticity (Kaneko and Stryker, 2014)."
      },
      {
        "n": 3812,
        "doi": "10.7554/elife.85893.sa0",
        "value": "40% of",
        "cite_key": "Nelson2023a",
        "n_definition": "varies - mice, neurons, or recordings",
        "scope_region": "varies by study",
        "scope_population": "VIP interneurons",
        "value_source_sentence": "INs that express the Ca2+ binding protein parvalbumin (PV), which account for ~40% of the GABAergic INs in neocortex, exhibit fast-spiking properties, with most projecting their axons to form perisomatic baskets on nearby pyramidal neuron soma (Hu et al., 2014)."
      },
      {
        "n": 3812,
        "doi": "10.7554/elife.85893.sa1",
        "value": "40% of",
        "cite_key": "Nelson2023b",
        "n_definition": "varies - mice, neurons, or recordings",
        "scope_region": "varies by study",
        "scope_population": "VIP interneurons",
        "value_source_sentence": "INs that express the Ca2+ binding protein parvalbumin (PV), which account for ~40% of the GABAergic INs in neocortex, exhibit fast-spiking properties, with most projecting their axons to form perisomatic baskets on nearby pyramidal neuron soma (Hu et al., 2014)."
      },
      {
        "n": 1059,
        "doi": "10.7554/elife.57749.sa2",
        "value": "97% of",
        "cite_key": "Granger2020",
        "n_definition": "varies - mice, neurons, or recordings",
        "scope_region": "varies by study",
        "scope_population": "VIP interneurons",
        "value_source_sentence": "We confirmed that Cre expression faithfully reports Chat expression in cerebral cortex using fluorescent in situ hybdrization (FISH), with 97% of Chat+ neurons expressing Cre and 100% of Cre+ neurons expressing Chat (Figure 1B)."
      },
      {
        "n": 1124,
        "doi": "10.7554/elife.14985.013",
        "value": "4% of",
        "cite_key": "Pakan2016b",
        "n_definition": "varies - mice, neurons, or recordings",
        "scope_region": "varies by study",
        "scope_population": "VIP interneurons",
        "value_source_sentence": "During visual stimulation, 47 ± 4% of excitatory neurons were significantly locomotion responsive (see Materials and methods for locomotion responsive criteria), compared with 28 ± 4% in darkness."
      },
      {
        "n": 5,
        "doi": "10.1113/jp288309",
        "value": "5 (from abstract context)",
        "cite_key": "Preuss2026",
        "n_definition": "varies - mice, neurons, or recordings",
        "scope_region": "varies by study",
        "scope_population": "VIP interneurons",
        "value_source_sentence": "Layer (L) 5 is a hub in the cortical column in which a multitude of feedforward and feedback pathways converge."
      },
      {
        "n": null,
        "doi": "10.1111/apha.70162",
        "value": "4 (from abstract context)",
        "cite_key": "Jabonska2026",
        "n_definition": "varies - mice, neurons, or recordings",
        "scope_region": "varies by study",
        "scope_population": "VIP interneurons",
        "value_source_sentence": "<h4>Aim</h4>Control of synaptic inhibition at the network level is essential for neuronal computation; however, the mechanism by which inhibitory I → I synapses between interneurons adjust their strength remains unclear."
      },
      {
        "n": 65,
        "doi": "10.1038/s41598-018-30958-w",
        "value": "1 (from abstract context)",
        "cite_key": "Camillo2018",
        "n_definition": "varies - mice, neurons, or recordings",
        "scope_region": "varies by study",
        "scope_population": "VIP interneurons",
        "value_source_sentence": "The largest group of interneurons in the upper layers of mouse primary visual cortex (V1) is formed by cells expressing the calcium-binding protein calretinin (CR)."
      }
    ],
    "x_axis": "Study / Cortical Area",
    "y_axis": "Effect size (varied metrics)",
    "n_analyzed": "varies",
    "n_definition": "varies across studies",
    "scope_region": "multiple cortical areas",
    "comparison_name": "VIP disinhibition effect sizes across studies",
    "comparison_type": "cross_study",
    "taxonomic_level": "VIP Cre-defined population (not subtype-resolved)",
    "scope_population": "VIP interneurons and their postsynaptic targets",
    "homogeneity_check": {
      "caveats": [
        "Effect sizes measured with different metrics (percent change, fold change, spike rate change)",
        "Different cortical areas studied",
        "Different behavioral states (anesthetized vs awake vs locomoting)",
        "Different stimulation protocols (optogenetic power, duration)",
        "n_definition varies across studies (mice vs neurons vs recordings)"
      ],
      "comparable": false
    }
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    "paper:paper-e012a8b94c60",
    "paper:paper-f22eb24f5525",
    "paper:paper-f842a578a511"
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  "section_title": "VIP Interneuron Function and Disinhibition",
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