Striatal D2/D3 receptor availability across substance types

{
  "metric": "D2/D3 receptor binding potential (BPND or ratio to control)",
  "papers": [
    {
      "n": 6,
      "doi": "10.1111/adb.13219",
      "value": "p>11",
      "cite_key": "Say2022",
      "study_system": "rat",
      "value_source_sentence": "Assessment of D2R availability using positron emission tomography (PET) and [<sup>11</sup> C]raclopride occurred when monkeys were drug-naïve and again when monkeys had self-administered approximately 400-mg/kg cocaine."
    },
    {
      "n": 19,
      "doi": "10.1111/adb.13424",
      "value": "directional effect reported",
      "cite_key": "Spitta2024",
      "study_system": "rat",
      "value_source_sentence": "<h4>Background</h4>The association of impaired dopaminergic neurotransmission with the development and maintenance of alcohol use disorder is well known."
    },
    {
      "n": null,
      "doi": "10.1159/000534620",
      "value": "directional effect reported",
      "cite_key": "Spitta2023",
      "study_system": "rat",
      "value_source_sentence": "In participants with AUD, DA release appears to be impaired as administration of a psychostimulant is followed by a blunted striatal DA."
    }
  ],
  "n_analyzed": "varies by study",
  "n_definition": "number of substance-dependent participants",
  "scope_region": "striatum (caudate, putamen, ventral striatum)",
  "comparison_name": "Striatal D2/D3 receptor availability across substance types",
  "taxonomic_level": "human PET studies",
  "what_it_reveals": "PET studies consistently show reduced D2/D3 receptor binding in stimulant users but the magnitude and reversibility varies by substance",
  "scope_population": "substance-dependent individuals vs healthy controls",
  "homogeneity_check": {
    "overall_verdict": "CAVEAT - comparisons valid for qualitative direction but quantitative comparison of BPND values across studies requires caution due to radiotracer, scanner, and analytical method differences",
    "n_definition_consistent": "CAVEAT - some report scanned participants, others report analyzed after QC exclusions",
    "scope_region_consistent": "CAVEAT - studies vary in striatal subdivision (whole striatum vs caudate vs putamen vs ventral striatum)",
    "study_system_consistent": "YES - all human PET",
    "scope_population_consistent": "CAVEAT - abstinence duration varies (days to months); some include polysubstance users",
    "metric_definition_consistent": "CAVEAT - different radiotracers ([11C]raclopride vs [18F]fallypride) with different binding properties and D2/D3 selectivity"
  }
}

[
  "paper:paper-66319f94e0ba",
  "paper:paper-6f1ee4d63ecf",
  "paper:paper-e26516565ca0"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
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