Version history

{
  "kind": "infographic",
  "prompt": "PET studies consistently show reduced D2/D3 receptor binding in stimulant users but the magnitude and reversibility varies by substance",
  "provider": "other",
  "raw_fields": {
    "metric": "D2/D3 receptor binding potential (BPND or ratio to control)",
    "papers": [
      {
        "n": 6,
        "doi": "10.1111/adb.13219",
        "value": "p>11",
        "cite_key": "Say2022",
        "study_system": "rat",
        "value_source_sentence": "Assessment of D2R availability using positron emission tomography (PET) and [<sup>11</sup> C]raclopride occurred when monkeys were drug-naïve and again when monkeys had self-administered approximately 400-mg/kg cocaine."
      },
      {
        "n": 19,
        "doi": "10.1111/adb.13424",
        "value": "directional effect reported",
        "cite_key": "Spitta2024",
        "study_system": "rat",
        "value_source_sentence": "<h4>Background</h4>The association of impaired dopaminergic neurotransmission with the development and maintenance of alcohol use disorder is well known."
      },
      {
        "n": null,
        "doi": "10.1159/000534620",
        "value": "directional effect reported",
        "cite_key": "Spitta2023",
        "study_system": "rat",
        "value_source_sentence": "In participants with AUD, DA release appears to be impaired as administration of a psychostimulant is followed by a blunted striatal DA."
      }
    ],
    "n_analyzed": "varies by study",
    "n_definition": "number of substance-dependent participants",
    "scope_region": "striatum (caudate, putamen, ventral striatum)",
    "comparison_name": "Striatal D2/D3 receptor availability across substance types",
    "taxonomic_level": "human PET studies",
    "what_it_reveals": "PET studies consistently show reduced D2/D3 receptor binding in stimulant users but the magnitude and reversibility varies by substance",
    "scope_population": "substance-dependent individuals vs healthy controls",
    "homogeneity_check": {
      "overall_verdict": "CAVEAT - comparisons valid for qualitative direction but quantitative comparison of BPND values across studies requires caution due to radiotracer, scanner, and analytical method differences",
      "n_definition_consistent": "CAVEAT - some report scanned participants, others report analyzed after QC exclusions",
      "scope_region_consistent": "CAVEAT - studies vary in striatal subdivision (whole striatum vs caudate vs putamen vs ventral striatum)",
      "study_system_consistent": "YES - all human PET",
      "scope_population_consistent": "CAVEAT - abstinence duration varies (days to months); some include polysubstance users",
      "metric_definition_consistent": "CAVEAT - different radiotracers ([11C]raclopride vs [18F]fallypride) with different binding properties and D2/D3 selectivity"
    }
  },
  "section_id": "section_04_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_04_evidence.json",
  "target_ref": "wiki_page:computationalreviewaddiction-04",
  "review_repo": "ComputationalReviewAddiction",
  "section_ref": "wiki_page:computationalreviewaddiction-04",
  "source_path": "evidence/section_04_evidence.json",
  "source_refs": [
    "paper:paper-66319f94e0ba",
    "paper:paper-6f1ee4d63ecf",
    "paper:paper-e26516565ca0"
  ],
  "section_title": "Dopamine Dynamics: Beyond Reward Prediction Error",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_04_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}