Short-term Depression at PV Basket Cell Synapses Across Brain Regions

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1113/jp286284",
      "value": "profound short-term depression",
      "method": "whole-cell paired recordings",
      "metric": "Paired-pulse ratio at PV BC to pyramidal cell synapses",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "paired recordings",
      "scope_region": "medial prefrontal cortex",
      "study_system": "mouse mPFC",
      "taxonomic_level": "cell type",
      "scope_population": "PV basket cells",
      "value_source_sentence": "unitary inhibitory postsynaptic currents in PNs were more reliably evoked by PVBCs than by CCKBCs, yet the former connections showed profound short-term depression.",
      "experimental_conditions": "in vitro paired recordings, room temperature"
    },
    {
      "n": 0,
      "doi": "10.1111/j.1460-9568.2010.07292.x",
      "value": "short-term depression at FSBC-pyramidal cell pairs, suppressed by carbachol",
      "method": "whole-cell paired recordings from identified interneurons",
      "metric": "Short-term depression at FSBC synapses",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "paired recordings",
      "scope_region": "CA3 hippocampus",
      "study_system": "mouse CA3 hippocampus",
      "taxonomic_level": "cell type",
      "scope_population": "fast-spiking basket cells",
      "value_source_sentence": "carbachol suppressed or even eliminated the short-term depression of uIPSCs in FSBC- and AAC-pyramidal cell pairs in a frequency-dependent manner.",
      "experimental_conditions": "in vitro paired recordings"
    },
    {
      "n": 0,
      "doi": "10.1152/jn.00167.2014",
      "value": "PPD and MPD magnitude increased with stimulation frequency; muscarine reduced initial pr twofold",
      "method": "whole-cell paired recordings, variance-mean analysis",
      "metric": "Paired-pulse depression at PV BC synapses",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "paired recordings",
      "scope_region": "CA1 hippocampus",
      "study_system": "mouse CA1 hippocampus, juvenile PV-GFP mice",
      "taxonomic_level": "cell type",
      "scope_population": "PV basket cells",
      "value_source_sentence": "mAChR activation reduced the presynaptic calcium transient fourfold and initial pr twofold, thereby reducing PPD.",
      "experimental_conditions": "in vitro paired recordings, 10 μM muscarine"
    }
  ],
  "comparison_id": "pvbc-std-across-regions",
  "comparison_name": "Short-term Depression at PV Basket Cell Synapses Across Brain Regions",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "PV basket cell synapses consistently show short-term depression across hippocampal and cortical regions, with the degree modifiable by cholinergic input. This convergence establishes STD as a fundamental property of PV output synapses.",
  "homogeneity_check": {
    "caveats": [
      "Brain regions differ (mPFC vs CA3 vs CA1)",
      "Age/species may differ across studies",
      "Temperature and recording conditions vary"
    ],
    "n_definition_uniform": "true",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-4d0daef43dfa",
  "paper:paper-7546e7b4175f",
  "paper:paper-cd913aa53986"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}