Version history

{
  "kind": "infographic",
  "prompt": "PV basket cell synapses consistently show short-term depression across hippocampal and cortical regions, with the degree modifiable by cholinergic input. This convergence establishes STD as a fundamental property of PV output synapses.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1113/jp286284",
        "value": "profound short-term depression",
        "method": "whole-cell paired recordings",
        "metric": "Paired-pulse ratio at PV BC to pyramidal cell synapses",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "paired recordings",
        "scope_region": "medial prefrontal cortex",
        "study_system": "mouse mPFC",
        "taxonomic_level": "cell type",
        "scope_population": "PV basket cells",
        "value_source_sentence": "unitary inhibitory postsynaptic currents in PNs were more reliably evoked by PVBCs than by CCKBCs, yet the former connections showed profound short-term depression.",
        "experimental_conditions": "in vitro paired recordings, room temperature"
      },
      {
        "n": 0,
        "doi": "10.1111/j.1460-9568.2010.07292.x",
        "value": "short-term depression at FSBC-pyramidal cell pairs, suppressed by carbachol",
        "method": "whole-cell paired recordings from identified interneurons",
        "metric": "Short-term depression at FSBC synapses",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "paired recordings",
        "scope_region": "CA3 hippocampus",
        "study_system": "mouse CA3 hippocampus",
        "taxonomic_level": "cell type",
        "scope_population": "fast-spiking basket cells",
        "value_source_sentence": "carbachol suppressed or even eliminated the short-term depression of uIPSCs in FSBC- and AAC-pyramidal cell pairs in a frequency-dependent manner.",
        "experimental_conditions": "in vitro paired recordings"
      },
      {
        "n": 0,
        "doi": "10.1152/jn.00167.2014",
        "value": "PPD and MPD magnitude increased with stimulation frequency; muscarine reduced initial pr twofold",
        "method": "whole-cell paired recordings, variance-mean analysis",
        "metric": "Paired-pulse depression at PV BC synapses",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "paired recordings",
        "scope_region": "CA1 hippocampus",
        "study_system": "mouse CA1 hippocampus, juvenile PV-GFP mice",
        "taxonomic_level": "cell type",
        "scope_population": "PV basket cells",
        "value_source_sentence": "mAChR activation reduced the presynaptic calcium transient fourfold and initial pr twofold, thereby reducing PPD.",
        "experimental_conditions": "in vitro paired recordings, 10 μM muscarine"
      }
    ],
    "comparison_id": "pvbc-std-across-regions",
    "comparison_name": "Short-term Depression at PV Basket Cell Synapses Across Brain Regions",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "PV basket cell synapses consistently show short-term depression across hippocampal and cortical regions, with the degree modifiable by cholinergic input. This convergence establishes STD as a fundamental property of PV output synapses.",
    "homogeneity_check": {
      "caveats": [
        "Brain regions differ (mPFC vs CA3 vs CA1)",
        "Age/species may differ across studies",
        "Temperature and recording conditions vary"
      ],
      "n_definition_uniform": "true",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
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  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json",
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  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-4d0daef43dfa",
    "paper:paper-7546e7b4175f",
    "paper:paper-cd913aa53986"
  ],
  "section_title": "Synaptic Physiology: Input Specificity, Output Targeting, and Short-Term Dynamics",
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
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}