PV Interneuron Firing During Different Hippocampal Oscillatory States

PV interneurons maintain consistent temporal relationships with pyramidal cell output across different hippocampal oscillatory states (theta, gamma, ripples), but their functional role shifts: during gamma they provide phase-locked pacing, during ripples they are necessary for oscillation generation, and across frequencies they maintain invariant temporal ordering. This supports a unified model of PV-mediated temporal coordination.

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1523/jneurosci.1685-07.2007",
      "value": "phase-locked to gamma oscillations with cell-type-specific tuning",
      "method": "juxtacellular recording + post-hoc identification",
      "metric": "PV basket cell firing during gamma oscillations",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "identified neurons",
      "scope_region": "hippocampus CA1",
      "study_system": "rat, hippocampus CA1, juxtacellular recording",
      "taxonomic_level": "PV+ basket cells",
      "scope_population": "PV+ basket cells",
      "value_source_sentence": "Cell type-specific tuning of hippocampal interneuron firing during gamma oscillations in vivo",
      "experimental_conditions": "freely moving"
    },
    {
      "n": 0,
      "doi": "10.1016/j.neuron.2014.06.023",
      "value": "PV activation paces ensemble spiking; PV silencing aborts ripples",
      "method": "multisite optogenetics + silicon probes",
      "metric": "PV interneuron role during sharp-wave ripples",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "recording sites",
      "scope_region": "hippocampus",
      "study_system": "rodent, hippocampus, multisite optogenetics",
      "taxonomic_level": "PV+ interneurons",
      "scope_population": "PV+ interneurons",
      "value_source_sentence": "Localized PV interneuron activation paced ensemble spiking",
      "experimental_conditions": "freely behaving"
    },
    {
      "n": 0,
      "doi": "10.1073/pnas.1210929109",
      "value": "frequency-invariant temporal ordering across theta and gamma",
      "method": "juxtacellular recording + labeling",
      "metric": "PV interneuron timing during theta oscillations in awake mice",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "identified neurons",
      "scope_region": "hippocampus",
      "study_system": "mouse, hippocampus, juxtacellular recording awake",
      "taxonomic_level": "hippocampal interneurons",
      "scope_population": "identified interneurons including PV+",
      "value_source_sentence": "Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice",
      "experimental_conditions": "awake head-fixed"
    }
  ],
  "comparison_id": "pv-interneuron-during-hippocampal-oscillations",
  "comparison_name": "PV Interneuron Firing During Different Hippocampal Oscillatory States",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "PV interneurons maintain consistent temporal relationships with pyramidal cell output across different hippocampal oscillatory states (theta, gamma, ripples), but their functional role shifts: during gamma they provide phase-locked pacing, during ripples they are necessary for oscillation generation, and across frequencies they maintain invariant temporal ordering. This supports a unified model of PV-mediated temporal coordination.",
  "homogeneity_check": {
    "caveats": [
      "Rat vs mouse species differences",
      "Different behavioral states (freely moving vs head-fixed vs anesthetized in some)",
      "PV basket cells specifically vs broader PV+ population"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "true",
    "taxonomic_level_uniform": "false",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "phase plot"
}

[
  "paper:paper-200e9cbf484c",
  "paper:paper-208b392bff06",
  "paper:paper-b35c7669727a"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}