Version history

{
  "kind": "infographic",
  "prompt": "PV interneurons maintain consistent temporal relationships with pyramidal cell output across different hippocampal oscillatory states (theta, gamma, ripples), but their functional role shifts: during gamma they provide phase-locked pacing, during ripples they are necessary for oscillation generation, and across frequencies they maintain invariant temporal ordering. This supports a unified model of PV-mediated temporal coordination.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1523/jneurosci.1685-07.2007",
        "value": "phase-locked to gamma oscillations with cell-type-specific tuning",
        "method": "juxtacellular recording + post-hoc identification",
        "metric": "PV basket cell firing during gamma oscillations",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "identified neurons",
        "scope_region": "hippocampus CA1",
        "study_system": "rat, hippocampus CA1, juxtacellular recording",
        "taxonomic_level": "PV+ basket cells",
        "scope_population": "PV+ basket cells",
        "value_source_sentence": "Cell type-specific tuning of hippocampal interneuron firing during gamma oscillations in vivo",
        "experimental_conditions": "freely moving"
      },
      {
        "n": 0,
        "doi": "10.1016/j.neuron.2014.06.023",
        "value": "PV activation paces ensemble spiking; PV silencing aborts ripples",
        "method": "multisite optogenetics + silicon probes",
        "metric": "PV interneuron role during sharp-wave ripples",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "recording sites",
        "scope_region": "hippocampus",
        "study_system": "rodent, hippocampus, multisite optogenetics",
        "taxonomic_level": "PV+ interneurons",
        "scope_population": "PV+ interneurons",
        "value_source_sentence": "Localized PV interneuron activation paced ensemble spiking",
        "experimental_conditions": "freely behaving"
      },
      {
        "n": 0,
        "doi": "10.1073/pnas.1210929109",
        "value": "frequency-invariant temporal ordering across theta and gamma",
        "method": "juxtacellular recording + labeling",
        "metric": "PV interneuron timing during theta oscillations in awake mice",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "identified neurons",
        "scope_region": "hippocampus",
        "study_system": "mouse, hippocampus, juxtacellular recording awake",
        "taxonomic_level": "hippocampal interneurons",
        "scope_population": "identified interneurons including PV+",
        "value_source_sentence": "Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice",
        "experimental_conditions": "awake head-fixed"
      }
    ],
    "comparison_id": "pv-interneuron-during-hippocampal-oscillations",
    "comparison_name": "PV Interneuron Firing During Different Hippocampal Oscillatory States",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "PV interneurons maintain consistent temporal relationships with pyramidal cell output across different hippocampal oscillatory states (theta, gamma, ripples), but their functional role shifts: during gamma they provide phase-locked pacing, during ripples they are necessary for oscillation generation, and across frequencies they maintain invariant temporal ordering. This supports a unified model of PV-mediated temporal coordination.",
    "homogeneity_check": {
      "caveats": [
        "Rat vs mouse species differences",
        "Different behavioral states (freely moving vs head-fixed vs anesthetized in some)",
        "PV basket cells specifically vs broader PV+ population"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "true",
      "taxonomic_level_uniform": "false",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "phase plot"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-08",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-08",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-200e9cbf484c",
    "paper:paper-208b392bff06",
    "paper:paper-b35c7669727a"
  ],
  "section_title": "In Vivo Dynamics and Behavioural Correlates",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}