Simultaneous dopamine and serotonin measurements across brain regions and behav…

{
  "title": "Simultaneous dopamine and serotonin measurements across brain regions and behavioral states",
  "papers": [
    {
      "n": 5,
      "doi": "10.1016/j.neuron.2020.09.015",
      "value": "Sub-second DA and 5-HT simultaneously measured in caudate nucleus",
      "n_analyzed": 5,
      "n_definition": "patients with electrode placements",
      "scope_region": "caudate nucleus and putamen",
      "study_system": "human, intraoperative FSCV",
      "scope_population": "neurosurgery patients",
      "value_source_sentence": "Caudate nucleus recordings (n = 4) revealed multi-scale encoding: in three participants, serotonin tracked sensory uncertainty, and, in one participant, both dopamine and serotonin tracked deviations from expected trial transitions within our factorial design."
    },
    {
      "n": null,
      "doi": "10.7554/elife.85011",
      "value": "CIN activity ramps co-occur with DA release ramps during motivated approach in NAc",
      "n_analyzed": null,
      "n_definition": "animals with dual fiber photometry",
      "scope_region": "nucleus accumbens core",
      "study_system": "rat, nucleus accumbens fiber photometry",
      "scope_population": "adult rats",
      "value_source_sentence": "In an operant task, we observed fast ramps in CIN activity during approach behaviors, either to start the trial or to collect rewards. These CIN ramps co-occurred with DA release ramps, without corresponding changes in the firing of lateral VTA DA neurons."
    },
    {
      "n": null,
      "doi": "10.1126/science.abn0532",
      "value": "DA release area 3-4x larger than ACh signaling domain; nAChR blockade strongly reduces DA spread",
      "n_analyzed": null,
      "n_definition": "animals/slices",
      "scope_region": "dorsal and ventral striatum",
      "study_system": "mouse, striatal slices and in vivo",
      "scope_population": "adult mice",
      "value_source_sentence": "evoked dopamine release covered an area three to four times larger than evoked ACh release, and nAChR blockade strongly reduced its area"
    }
  ],
  "x_axis": "Brain region / behavioral paradigm",
  "y_axis": "Neuromodulator signal characteristics",
  "figure_id": "fig_sec8_DA_5HT_signaling",
  "comparison_type": "cross-study quantitative comparison",
  "homogeneity_check": {
    "caveats": [
      "Different species: human (FSCV) vs rat (fiber photometry) vs mouse (GRAB sensors/slices)",
      "Different measurement techniques: FSCV measures concentration changes, fiber photometry measures fluorescent reporter activity, two-photon imaging measures sensor fluorescence",
      "Different brain regions: caudate vs NAc core vs dorsal/ventral striatum",
      "Different temporal resolution: sub-second FSCV vs fiber photometry ~100ms",
      "Values are qualitative comparisons rather than directly comparable quantitative measures"
    ],
    "comparable": false
  }
}

[
  "paper:paper-75a21c46eddb",
  "paper:paper-7e7ac00e250f",
  "paper:paper-cbb676f4b880"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}