Version history

{
  "kind": "infographic",
  "prompt": "Simultaneous dopamine and serotonin measurements across brain regions and behavioral states",
  "provider": "other",
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    "title": "Simultaneous dopamine and serotonin measurements across brain regions and behavioral states",
    "papers": [
      {
        "n": 5,
        "doi": "10.1016/j.neuron.2020.09.015",
        "value": "Sub-second DA and 5-HT simultaneously measured in caudate nucleus",
        "n_analyzed": 5,
        "n_definition": "patients with electrode placements",
        "scope_region": "caudate nucleus and putamen",
        "study_system": "human, intraoperative FSCV",
        "scope_population": "neurosurgery patients",
        "value_source_sentence": "Caudate nucleus recordings (n = 4) revealed multi-scale encoding: in three participants, serotonin tracked sensory uncertainty, and, in one participant, both dopamine and serotonin tracked deviations from expected trial transitions within our factorial design."
      },
      {
        "n": null,
        "doi": "10.7554/elife.85011",
        "value": "CIN activity ramps co-occur with DA release ramps during motivated approach in NAc",
        "n_analyzed": null,
        "n_definition": "animals with dual fiber photometry",
        "scope_region": "nucleus accumbens core",
        "study_system": "rat, nucleus accumbens fiber photometry",
        "scope_population": "adult rats",
        "value_source_sentence": "In an operant task, we observed fast ramps in CIN activity during approach behaviors, either to start the trial or to collect rewards. These CIN ramps co-occurred with DA release ramps, without corresponding changes in the firing of lateral VTA DA neurons."
      },
      {
        "n": null,
        "doi": "10.1126/science.abn0532",
        "value": "DA release area 3-4x larger than ACh signaling domain; nAChR blockade strongly reduces DA spread",
        "n_analyzed": null,
        "n_definition": "animals/slices",
        "scope_region": "dorsal and ventral striatum",
        "study_system": "mouse, striatal slices and in vivo",
        "scope_population": "adult mice",
        "value_source_sentence": "evoked dopamine release covered an area three to four times larger than evoked ACh release, and nAChR blockade strongly reduced its area"
      }
    ],
    "x_axis": "Brain region / behavioral paradigm",
    "y_axis": "Neuromodulator signal characteristics",
    "figure_id": "fig_sec8_DA_5HT_signaling",
    "comparison_type": "cross-study quantitative comparison",
    "homogeneity_check": {
      "caveats": [
        "Different species: human (FSCV) vs rat (fiber photometry) vs mouse (GRAB sensors/slices)",
        "Different measurement techniques: FSCV measures concentration changes, fiber photometry measures fluorescent reporter activity, two-photon imaging measures sensor fluorescence",
        "Different brain regions: caudate vs NAc core vs dorsal/ventral striatum",
        "Different temporal resolution: sub-second FSCV vs fiber photometry ~100ms",
        "Values are qualitative comparisons rather than directly comparable quantitative measures"
      ],
      "comparable": false
    }
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  "section_title": "Cross-System Interactions and Brain-Wide States",
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