3. Paired-recording evidence in mouse — connection probabilities and synaptic s…

{
  "id": "projection_class_specific_EE_matrix",
  "type": "projection-class connectivity matrix",
  "description": "Connection probability and bias of E->E connections by long-range projection class (IT, PT, CT) in mouse cortex.",
  "audit_issues": [
    {
      "dimension": "metric_definition",
      "description": "Sources describe projection-target-specific E→E connectivity at different resolutions (corticospinal/corticostriatal segregation, full CT/IT/PT motif matrix, hierarchical M1 wiring, L5 projection-class diversity). Reported quantities are not identical but address overlapping pieces of the same matrix.",
      "entries_affected": [
        "10.1038/nn.2701",
        "10.1038/nature07658",
        "10.1523/jneurosci.4023-14.2015",
        "10.1523/jneurosci.4759-11.2012",
        "10.3389/fncel.2013.00174"
      ]
    },
    {
      "dimension": "scope_population",
      "description": "Some entries probe broad CT/IT/PT classes; others probe L5 projection diversity at finer Cre-line resolution. Plotting on a single matrix risks conflating resolutions.",
      "entries_affected": [
        "10.1038/nn.2701",
        "10.1038/nature07658",
        "10.1523/jneurosci.4023-14.2015",
        "10.1523/jneurosci.4759-11.2012",
        "10.3389/fncel.2013.00174"
      ]
    }
  ],
  "audit_verdict": "CAVEAT",
  "section_targets": [
    "section_03"
  ],
  "comparable_sources": [
    {
      "doi": "10.1038/nature07658",
      "pmid": "19151698",
      "what": "Brown/Hestrin 2009 — projection-target-specific pyramidal-pyramidal connectivity"
    },
    {
      "doi": "10.1523/jneurosci.4023-14.2015",
      "pmid": "25653383",
      "what": "Yamawaki/Shepherd 2015 mouse M1 CT/IT/PT motifs"
    },
    {
      "doi": "10.1523/jneurosci.4759-11.2012",
      "pmid": "22492054",
      "what": "Kiritani/Shepherd 2012 hierarchical M1 corticospinal-corticostriatal"
    },
    {
      "doi": "10.3389/fncel.2013.00174",
      "pmid": "24137110",
      "what": "Suter 2013 — mouse M1 L5 diversity of projection neuron classes"
    }
  ],
  "primary_source_doi": "10.1038/nn.2701",
  "primary_source_pmid": "20436481",
  "notes_for_extraction": "Cross-comparison of E->E P(connection) and amplitude by projection target: Anderson/Shepherd 2010 (M1 L2/3→L5 CSp vs CSt), Brown/Hestrin 2009 (projection-target dependence), Yamawaki/Shepherd 2015 (CT vs IT vs PT in M1 L6), Otsuka/Kawaguchi-style L5 motor diversity (24137110).",
  "claim_source_sentence": "The main excitatory pathway in mouse motor cortex, layer 2/3->5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons.",
  "audit_fabrication_flag": "Label 'Suter 2013' on DOI 10.3389/fncel.2013.00174 does not match DOI authors (Tantirigama, Sonntag, Hughes, Empson, Oswald). The Suter & Shepherd 2013 paper that the label likely intends is at a different DOI. Coordinator should reconcile.",
  "mandatory_caption_caveats": [
    "Entries report different slices of the M1 projection-class connectivity matrix (corticospinal/corticostriatal segregation, CT/IT/PT motifs, L5 sub-diversity) — values are complementary, not directly equivalent.",
    "Verify the 'Suter 2013' label on DOI 10.3389/fncel.2013.00174 (DOI maps to Tantirigama et al. 2013, not Suter)."
  ]
}

[]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}