VIP→SST Disinhibitory Circuit: Evidence Across Cortical Areas and Behavioral Co…

{
  "papers": [
    {
      "doi": "10.1038/nature12676",
      "value": "VIP activation suppresses SST and PV neurons during auditory discrimination",
      "method": "optogenetics + electrophysiology",
      "metric": "VIP-SST circuit recruitment",
      "cite_key": "Pi2013",
      "condition": "auditory cortex, discrimination task",
      "study_system": "mouse",
      "value_source_sentence": "During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex."
    },
    {
      "doi": "10.1038/nn.3544",
      "value": "VIP disinhibition mediates motor integration in S1",
      "method": "optogenetics + electrophysiology",
      "metric": "VIP-SST circuit recruitment",
      "cite_key": "Lee2013",
      "condition": "S1, motor integration",
      "study_system": "mouse",
      "value_source_sentence": "A disinhibitory circuit mediates motor integration in the somatosensory cortex."
    },
    {
      "doi": "10.7554/elife.05558",
      "value": "VIP-SST disinhibition enables adult plasticity during locomotion",
      "method": "calcium imaging + optogenetics",
      "metric": "VIP-SST circuit recruitment",
      "cite_key": "Fu2015",
      "condition": "V1, locomotion + plasticity",
      "study_system": "mouse",
      "value_source_sentence": "A cortical disinhibitory circuit for enhancing adult plasticity."
    },
    {
      "doi": "10.1016/j.celrep.2023.113133",
      "value": "Top-down ACa input activates VIP and inhibits SST for deviance detection",
      "method": "two-photon imaging + optogenetics",
      "metric": "VIP-SST circuit recruitment",
      "cite_key": "Bastos2023a",
      "condition": "V1, oddball paradigm",
      "study_system": "mouse",
      "value_source_sentence": "Optogenetic drive of ACa-V1 inputs at 10 Hz activated V1-VIPs but inhibited V1-SSTs."
    },
    {
      "doi": "10.1038/nn.4002",
      "value": "Acetylcholine activates VIP-SST circuit via nicotinic receptors",
      "method": "in vitro + in vivo electrophysiology",
      "metric": "VIP-SST circuit recruitment",
      "cite_key": "Chen2015",
      "condition": "cortex, cholinergic modulation",
      "study_system": "mouse",
      "value_source_sentence": "An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity."
    },
    {
      "doi": "10.1038/nature10674",
      "value": "Disinhibition via L1 interneurons targeting SST mediates fear learning",
      "method": "optogenetics + electrophysiology",
      "metric": "VIP-SST-like disinhibitory circuit",
      "cite_key": "Letzkus2011",
      "condition": "auditory cortex, fear conditioning",
      "study_system": "mouse",
      "value_source_sentence": "A disinhibitory microcircuit for associative fear learning in the auditory cortex."
    }
  ],
  "comparison_id": "vip-sst-disinhibition-evidence",
  "comparison_name": "VIP→SST Disinhibitory Circuit: Evidence Across Cortical Areas and Behavioral Contexts",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "The VIP→SST→pyramidal disinhibitory motif is one of the most replicated circuit motifs in cortical interneuron research, validated across multiple areas and behavioral paradigms.",
  "homogeneity_check": {
    "caveats": [
      "All mouse studies, no cross-species data",
      "Different cortical areas but all showing the same motif"
    ],
    "comparable": true
  },
  "suggested_plot_type": "heatmap"
}

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  "paper:paper-2c3589e2f07a",
  "paper:paper-4126563ac4f2",
  "paper:paper-45d83bfad56d",
  "paper:paper-f02f24cb44ff",
  "paper:paper-f22eb24f5525"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}