Version history

{
  "kind": "infographic",
  "prompt": "The VIP→SST→pyramidal disinhibitory motif is one of the most replicated circuit motifs in cortical interneuron research, validated across multiple areas and behavioral paradigms.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/nature12676",
        "value": "VIP activation suppresses SST and PV neurons during auditory discrimination",
        "method": "optogenetics + electrophysiology",
        "metric": "VIP-SST circuit recruitment",
        "cite_key": "Pi2013",
        "condition": "auditory cortex, discrimination task",
        "study_system": "mouse",
        "value_source_sentence": "During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex."
      },
      {
        "doi": "10.1038/nn.3544",
        "value": "VIP disinhibition mediates motor integration in S1",
        "method": "optogenetics + electrophysiology",
        "metric": "VIP-SST circuit recruitment",
        "cite_key": "Lee2013",
        "condition": "S1, motor integration",
        "study_system": "mouse",
        "value_source_sentence": "A disinhibitory circuit mediates motor integration in the somatosensory cortex."
      },
      {
        "doi": "10.7554/elife.05558",
        "value": "VIP-SST disinhibition enables adult plasticity during locomotion",
        "method": "calcium imaging + optogenetics",
        "metric": "VIP-SST circuit recruitment",
        "cite_key": "Fu2015",
        "condition": "V1, locomotion + plasticity",
        "study_system": "mouse",
        "value_source_sentence": "A cortical disinhibitory circuit for enhancing adult plasticity."
      },
      {
        "doi": "10.1016/j.celrep.2023.113133",
        "value": "Top-down ACa input activates VIP and inhibits SST for deviance detection",
        "method": "two-photon imaging + optogenetics",
        "metric": "VIP-SST circuit recruitment",
        "cite_key": "Bastos2023a",
        "condition": "V1, oddball paradigm",
        "study_system": "mouse",
        "value_source_sentence": "Optogenetic drive of ACa-V1 inputs at 10 Hz activated V1-VIPs but inhibited V1-SSTs."
      },
      {
        "doi": "10.1038/nn.4002",
        "value": "Acetylcholine activates VIP-SST circuit via nicotinic receptors",
        "method": "in vitro + in vivo electrophysiology",
        "metric": "VIP-SST circuit recruitment",
        "cite_key": "Chen2015",
        "condition": "cortex, cholinergic modulation",
        "study_system": "mouse",
        "value_source_sentence": "An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity."
      },
      {
        "doi": "10.1038/nature10674",
        "value": "Disinhibition via L1 interneurons targeting SST mediates fear learning",
        "method": "optogenetics + electrophysiology",
        "metric": "VIP-SST-like disinhibitory circuit",
        "cite_key": "Letzkus2011",
        "condition": "auditory cortex, fear conditioning",
        "study_system": "mouse",
        "value_source_sentence": "A disinhibitory microcircuit for associative fear learning in the auditory cortex."
      }
    ],
    "comparison_id": "vip-sst-disinhibition-evidence",
    "comparison_name": "VIP→SST Disinhibitory Circuit: Evidence Across Cortical Areas and Behavioral Contexts",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "The VIP→SST→pyramidal disinhibitory motif is one of the most replicated circuit motifs in cortical interneuron research, validated across multiple areas and behavioral paradigms.",
    "homogeneity_check": {
      "caveats": [
        "All mouse studies, no cross-species data",
        "Different cortical areas but all showing the same motif"
      ],
      "comparable": true
    },
    "suggested_plot_type": "heatmap"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-08",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-08",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-065a0eae69a5",
    "paper:paper-2c3589e2f07a",
    "paper:paper-4126563ac4f2",
    "paper:paper-45d83bfad56d",
    "paper:paper-f02f24cb44ff",
    "paper:paper-f22eb24f5525"
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}