Paradoxical effect magnitude across ISN cortical area studies (mouse)

{
  "title": "Paradoxical effect magnitude across ISN cortical area studies (mouse)",
  "values": [
    {
      "se": 3.5,
      "area": "mouse V1+S1+motor (Sanzeni 2020)",
      "p_value": 0.046,
      "source_doi": "10.7554/eLife.54875",
      "n_inhibitory_units": 6,
      "median_initial_slope_spk_per_s": -6.9
    },
    {
      "area": "mouse A1 PV inactivation (Adesnik 2017)",
      "effect": "paradoxical increase in IPSCs",
      "source_doi": "10.1016/j.neuron.2017.06.019"
    },
    {
      "area": "model: 4-population (PYR/PV/SST/VIP) - paradoxical possible without ISN",
      "source_doi": "10.7554/eLife.49967"
    },
    {
      "area": "model: large-fraction perturbation needed for reliable detection",
      "source_doi": "10.1523/JNEUROSCI.0963-17.2017"
    }
  ],
  "variable_x": "cortical area / preparation",
  "variable_y": "initial slope of firing-rate response of inhibitory units to photoinhibition (spk/s)",
  "audit_issues": [
    {
      "dimension": "metric_definition",
      "description": "Only row 1 (Sanzeni 2020) has a numeric y-axis value in the declared units (spk/s). Row 2 reports a qualitative IPSC increase. Rows 3–4 are theory/model citations without empirical y-values. The figure as configured has only one plottable point on its stated axis.",
      "entries_affected": [
        "10.7554/eLife.54875",
        "10.1016/j.neuron.2017.06.019",
        "10.7554/eLife.49967",
        "10.1523/JNEUROSCI.0963-17.2017"
      ]
    },
    {
      "dimension": "study_system",
      "description": "Rows 1 and 2 are empirical (V1+S1+motor in vivo electrophysiology vs. A1 PV inactivation with IPSC read-out); rows 3 and 4 are computational-model citations supporting interpretation, not data points.",
      "entries_affected": [
        "10.7554/eLife.54875",
        "10.1016/j.neuron.2017.06.019",
        "10.7554/eLife.49967",
        "10.1523/JNEUROSCI.0963-17.2017"
      ]
    },
    {
      "dimension": "scope_population",
      "description": "Row 1's denominator is 6 inhibitory units across multiple areas. Row 2's denominator is IPSC measurements from PV-inactivation experiments. These are not the same quantity and not the same n-definition.",
      "entries_affected": [
        "10.7554/eLife.54875",
        "10.1016/j.neuron.2017.06.019"
      ]
    }
  ],
  "audit_verdict": "REDESIGN",
  "interpretation": "Across mouse V1, S1, motor, and A1, paradoxical responses of inhibitory units to broad inhibitory-population perturbation have been reported, with median initial slope −6.9 ± 3.5 spk/s in the Sanzeni 2020 multi-area study. Theory (Sanzeni-Mongillo 2020; Moore & Carlén 2018) shows the diagnostic value of paradoxical effect depends on whether a large fraction of inhibitory neurons is perturbed.",
  "data_source_doi": "10.7554/eLife.54875",
  "audit_fabrication_flag": "Label 'Adesnik 2017' on DOI 10.1016/j.neuron.2017.06.019 does not match DOI authors (Kato, Asinof, Isaacson). Adesnik et al. 2017 is a separate paper at a different DOI; the citation should be corrected before figure proceeds.",
  "mandatory_caption_caveats": [
    "Only one row has a numeric value in the declared y-axis units. Rows 3–4 are model/theory citations and rows 2 reports a qualitative IPSC observation.",
    "Verify the 'Adesnik 2017' label on DOI 10.1016/j.neuron.2017.06.019: the DOI maps to Kato, Asinof and Isaacson 2017 — Adesnik is not on the author list.",
    "Phase 7 writer: REDESIGN verdict — implement as: Restrict the figure to empirical paradoxical-effect measurements that report initial-slope (or equivalent firing-rate) responses in spk/s; cite the theory papers in the caption rather than plotting them. Resolve the Adesnik/Kato author/DOI mismatch first."
  ]
}

[]

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}