Version history

{
  "kind": "infographic",
  "prompt": "Paradoxical effect magnitude across ISN cortical area studies (mouse)",
  "provider": "other",
  "raw_fields": {
    "title": "Paradoxical effect magnitude across ISN cortical area studies (mouse)",
    "values": [
      {
        "se": 3.5,
        "area": "mouse V1+S1+motor (Sanzeni 2020)",
        "p_value": 0.046,
        "source_doi": "10.7554/eLife.54875",
        "n_inhibitory_units": 6,
        "median_initial_slope_spk_per_s": -6.9
      },
      {
        "area": "mouse A1 PV inactivation (Adesnik 2017)",
        "effect": "paradoxical increase in IPSCs",
        "source_doi": "10.1016/j.neuron.2017.06.019"
      },
      {
        "area": "model: 4-population (PYR/PV/SST/VIP) - paradoxical possible without ISN",
        "source_doi": "10.7554/eLife.49967"
      },
      {
        "area": "model: large-fraction perturbation needed for reliable detection",
        "source_doi": "10.1523/JNEUROSCI.0963-17.2017"
      }
    ],
    "variable_x": "cortical area / preparation",
    "variable_y": "initial slope of firing-rate response of inhibitory units to photoinhibition (spk/s)",
    "audit_issues": [
      {
        "dimension": "metric_definition",
        "description": "Only row 1 (Sanzeni 2020) has a numeric y-axis value in the declared units (spk/s). Row 2 reports a qualitative IPSC increase. Rows 3–4 are theory/model citations without empirical y-values. The figure as configured has only one plottable point on its stated axis.",
        "entries_affected": [
          "10.7554/eLife.54875",
          "10.1016/j.neuron.2017.06.019",
          "10.7554/eLife.49967",
          "10.1523/JNEUROSCI.0963-17.2017"
        ]
      },
      {
        "dimension": "study_system",
        "description": "Rows 1 and 2 are empirical (V1+S1+motor in vivo electrophysiology vs. A1 PV inactivation with IPSC read-out); rows 3 and 4 are computational-model citations supporting interpretation, not data points.",
        "entries_affected": [
          "10.7554/eLife.54875",
          "10.1016/j.neuron.2017.06.019",
          "10.7554/eLife.49967",
          "10.1523/JNEUROSCI.0963-17.2017"
        ]
      },
      {
        "dimension": "scope_population",
        "description": "Row 1's denominator is 6 inhibitory units across multiple areas. Row 2's denominator is IPSC measurements from PV-inactivation experiments. These are not the same quantity and not the same n-definition.",
        "entries_affected": [
          "10.7554/eLife.54875",
          "10.1016/j.neuron.2017.06.019"
        ]
      }
    ],
    "audit_verdict": "REDESIGN",
    "interpretation": "Across mouse V1, S1, motor, and A1, paradoxical responses of inhibitory units to broad inhibitory-population perturbation have been reported, with median initial slope −6.9 ± 3.5 spk/s in the Sanzeni 2020 multi-area study. Theory (Sanzeni-Mongillo 2020; Moore & Carlén 2018) shows the diagnostic value of paradoxical effect depends on whether a large fraction of inhibitory neurons is perturbed.",
    "data_source_doi": "10.7554/eLife.54875",
    "audit_fabrication_flag": "Label 'Adesnik 2017' on DOI 10.1016/j.neuron.2017.06.019 does not match DOI authors (Kato, Asinof, Isaacson). Adesnik et al. 2017 is a separate paper at a different DOI; the citation should be corrected before figure proceeds.",
    "mandatory_caption_caveats": [
      "Only one row has a numeric value in the declared y-axis units. Rows 3–4 are model/theory citations and rows 2 reports a qualitative IPSC observation.",
      "Verify the 'Adesnik 2017' label on DOI 10.1016/j.neuron.2017.06.019: the DOI maps to Kato, Asinof and Isaacson 2017 — Adesnik is not on the author list.",
      "Phase 7 writer: REDESIGN verdict — implement as: Restrict the figure to empirical paradoxical-effect measurements that report initial-slope (or equivalent firing-rate) responses in spk/s; cite the theory papers in the caption rather than plotting them. Resolve the Adesnik/Kato author/DOI mismatch first."
    ]
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}