PV cell reduction across psychiatric disorder mouse models

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1007/s11689-009-9023-x",
      "value": "reduced PV cells with asymmetric hemispheric distribution",
      "method": "immunohistochemistry PV cell counting",
      "metric": "PV cell count in neocortex",
      "n_analyzed": 0,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "mice per genotype",
      "scope_region": "neocortex (parietal and occipital)",
      "study_system": "VPA and NL-3 R451C ASD mouse models",
      "taxonomic_level": "single cell type (PV neurons)",
      "scope_population": "PV-positive interneurons",
      "value_source_sentence": "PV-cells were reduced in the neocortex across multiple ASD mouse models.",
      "experimental_conditions": "ASD models vs controls"
    },
    {
      "n": 0,
      "doi": "10.1523/jneurosci.5419-08.2009",
      "value": "decreased density in mPFC and ventral hippocampus",
      "method": "immunohistochemistry with stereological counting",
      "metric": "PV interneuron density in mPFC",
      "n_analyzed": 0,
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "rats per group",
      "scope_region": "mPFC and ventral hippocampus",
      "study_system": "MAM rat model of schizophrenia",
      "taxonomic_level": "single cell type (PV neurons)",
      "scope_population": "PV-positive interneurons",
      "value_source_sentence": "MAM-treated rats display a decreased density of parvalbumin-positive interneurons throughout the medial prefrontal cortex (mPFC) and ventral (but not dorsal) subiculum of the hippocampus.",
      "experimental_conditions": "MAM vs saline treated"
    },
    {
      "n": 0,
      "doi": "10.1038/nn.2447",
      "value": "reduced PV expression in NMDAR-ablated interneurons",
      "method": "immunohistochemistry, western blot",
      "metric": "PV protein expression in cortex",
      "n_analyzed": 0,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "mice per genotype",
      "scope_region": "cortex and hippocampus",
      "study_system": "NR1 deletion in corticolimbic interneurons (schizophrenia model)",
      "taxonomic_level": "interneuron subtype (PV-expressing)",
      "scope_population": "corticolimbic interneurons",
      "value_source_sentence": "Reduced expression of glutamic acid decarboxylase 67 and parvalbumin was accompanied by disinhibition of cortical excitatory neurons and reduced neuronal synchrony.",
      "experimental_conditions": "conditional knockout vs control"
    }
  ],
  "comparison_id": "pv-cell-reduction-across-psychiatric-mouse-models",
  "comparison_name": "PV cell reduction across psychiatric disorder mouse models",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "PV cell reduction is a convergent phenotype across ASD, schizophrenia, and NMDAR hypofunction models, supporting PV circuits as a shared vulnerability across neurodevelopmental disorders",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions examined: neocortex vs mPFC vs cortex+hippocampus",
      "Different species: mouse vs rat",
      "Different disease models with different etiologies",
      "Measurements are qualitative (decreased) without standardized effect sizes"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "forest plot"
}

[
  "paper:paper-31c511f98d76",
  "paper:paper-6b9d5ae87be7",
  "paper:paper-ca695afd0873"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}