Version history

{
  "kind": "infographic",
  "prompt": "PV cell reduction is a convergent phenotype across ASD, schizophrenia, and NMDAR hypofunction models, supporting PV circuits as a shared vulnerability across neurodevelopmental disorders",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1007/s11689-009-9023-x",
        "value": "reduced PV cells with asymmetric hemispheric distribution",
        "method": "immunohistochemistry PV cell counting",
        "metric": "PV cell count in neocortex",
        "n_analyzed": 0,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "mice per genotype",
        "scope_region": "neocortex (parietal and occipital)",
        "study_system": "VPA and NL-3 R451C ASD mouse models",
        "taxonomic_level": "single cell type (PV neurons)",
        "scope_population": "PV-positive interneurons",
        "value_source_sentence": "PV-cells were reduced in the neocortex across multiple ASD mouse models.",
        "experimental_conditions": "ASD models vs controls"
      },
      {
        "n": 0,
        "doi": "10.1523/jneurosci.5419-08.2009",
        "value": "decreased density in mPFC and ventral hippocampus",
        "method": "immunohistochemistry with stereological counting",
        "metric": "PV interneuron density in mPFC",
        "n_analyzed": 0,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "rats per group",
        "scope_region": "mPFC and ventral hippocampus",
        "study_system": "MAM rat model of schizophrenia",
        "taxonomic_level": "single cell type (PV neurons)",
        "scope_population": "PV-positive interneurons",
        "value_source_sentence": "MAM-treated rats display a decreased density of parvalbumin-positive interneurons throughout the medial prefrontal cortex (mPFC) and ventral (but not dorsal) subiculum of the hippocampus.",
        "experimental_conditions": "MAM vs saline treated"
      },
      {
        "n": 0,
        "doi": "10.1038/nn.2447",
        "value": "reduced PV expression in NMDAR-ablated interneurons",
        "method": "immunohistochemistry, western blot",
        "metric": "PV protein expression in cortex",
        "n_analyzed": 0,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "mice per genotype",
        "scope_region": "cortex and hippocampus",
        "study_system": "NR1 deletion in corticolimbic interneurons (schizophrenia model)",
        "taxonomic_level": "interneuron subtype (PV-expressing)",
        "scope_population": "corticolimbic interneurons",
        "value_source_sentence": "Reduced expression of glutamic acid decarboxylase 67 and parvalbumin was accompanied by disinhibition of cortical excitatory neurons and reduced neuronal synchrony.",
        "experimental_conditions": "conditional knockout vs control"
      }
    ],
    "comparison_id": "pv-cell-reduction-across-psychiatric-mouse-models",
    "comparison_name": "PV cell reduction across psychiatric disorder mouse models",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "PV cell reduction is a convergent phenotype across ASD, schizophrenia, and NMDAR hypofunction models, supporting PV circuits as a shared vulnerability across neurodevelopmental disorders",
    "homogeneity_check": {
      "caveats": [
        "Different brain regions examined: neocortex vs mPFC vs cortex+hippocampus",
        "Different species: mouse vs rat",
        "Different disease models with different etiologies",
        "Measurements are qualitative (decreased) without standardized effect sizes"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_11_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-11",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-11",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-31c511f98d76",
    "paper:paper-6b9d5ae87be7",
    "paper:paper-ca695afd0873"
  ],
  "section_title": "Species Translation, Human Data, and Disease Models",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}