PV vs SOM interneuron contribution to gamma oscillations across brain regions

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1038/nature07991",
      "value": "suppresses gamma",
      "method": "optogenetics + LFP",
      "metric": "Effect of PV inhibition on gamma power",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "mice",
      "scope_region": "neocortex",
      "study_system": "mouse neocortex",
      "taxonomic_level": "broad category",
      "scope_population": "PV interneurons",
      "value_source_sentence": "We find that inhibiting parvalbumin interneurons suppresses gamma oscillations in vivo.",
      "experimental_conditions": "in vivo PV optogenetic inhibition"
    },
    {
      "n": 0,
      "doi": "10.1038/nn.4562",
      "value": "SOM critical for context-dependent gamma",
      "method": "optogenetics + LFP + modeling",
      "metric": "Effect of SOM inhibition on gamma",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "mice",
      "scope_region": "primary visual cortex",
      "study_system": "mouse visual cortex",
      "taxonomic_level": "broad category",
      "scope_population": "SOM interneurons",
      "value_source_sentence": "Dendrite-targeting somatostatin (SOM) interneurons are critical for a visually induced, context-dependent gamma rhythm in the visual cortex (V1).",
      "experimental_conditions": "in vivo SOM optogenetic manipulation"
    },
    {
      "n": 0,
      "doi": "10.1523/jneurosci.0261-20.2020",
      "value": "both PV and SST disruption decreases slow gamma power",
      "method": "optogenetics + LFP in slice",
      "metric": "Effect of PV/SST disruption on hippocampal gamma",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "abstract_only",
      "n_definition": "mouse hippocampal slices",
      "scope_region": "hippocampus CA3",
      "study_system": "mouse hippocampal CA3 ex vivo",
      "taxonomic_level": "broad category",
      "scope_population": "PV and SST interneurons",
      "value_source_sentence": "Disrupting either PV+ or SST+ interneuron activity, via either photoinhibition or photoexcitation, led to a decrease in the power of cholinergically induced slow gamma oscillations.",
      "experimental_conditions": "optogenetic disruption of PV or SST"
    },
    {
      "n": 0,
      "doi": "10.7554/eLife.28569",
      "value": "SOM-dependent, PV-independent (30 Hz narrow band)",
      "method": "optogenetics + LFP in slice",
      "metric": "PV vs SOM dependence of V1 gamma",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "mouse brain slices",
      "scope_region": "primary visual cortex",
      "study_system": "mouse visual cortex brain slices",
      "taxonomic_level": "broad category",
      "scope_population": "SOM and PV interneurons",
      "value_source_sentence": "The network oscillations generated here depend on SOM neuron but not parvalbumin (PV) neuron activity.",
      "experimental_conditions": "optogenetic patterned illumination in acute slices"
    }
  ],
  "comparison_id": "pv-vs-som-gamma-contribution",
  "comparison_name": "PV vs SOM interneuron contribution to gamma oscillations across brain regions",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "The relative contribution of PV vs SOM interneurons to gamma depends critically on brain region, gamma subtype, and experimental preparation - challenging a simple PV-centric model",
  "homogeneity_check": {
    "caveats": [
      "Studies compare different brain regions (neocortex, V1, CA3)",
      "Mix of in vivo and in vitro preparations",
      "Different gamma subtypes (broad-band vs narrow 30 Hz vs slow gamma)"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "false"
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-4d3be038bd01",
  "paper:paper-676bfe401c07",
  "paper:paper-d5a7d63abc9a",
  "paper:paper-de315a7499ba"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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