Version history

{
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  "prompt": "The relative contribution of PV vs SOM interneurons to gamma depends critically on brain region, gamma subtype, and experimental preparation - challenging a simple PV-centric model",
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      {
        "n": 0,
        "doi": "10.1038/nature07991",
        "value": "suppresses gamma",
        "method": "optogenetics + LFP",
        "metric": "Effect of PV inhibition on gamma power",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "mice",
        "scope_region": "neocortex",
        "study_system": "mouse neocortex",
        "taxonomic_level": "broad category",
        "scope_population": "PV interneurons",
        "value_source_sentence": "We find that inhibiting parvalbumin interneurons suppresses gamma oscillations in vivo.",
        "experimental_conditions": "in vivo PV optogenetic inhibition"
      },
      {
        "n": 0,
        "doi": "10.1038/nn.4562",
        "value": "SOM critical for context-dependent gamma",
        "method": "optogenetics + LFP + modeling",
        "metric": "Effect of SOM inhibition on gamma",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "mice",
        "scope_region": "primary visual cortex",
        "study_system": "mouse visual cortex",
        "taxonomic_level": "broad category",
        "scope_population": "SOM interneurons",
        "value_source_sentence": "Dendrite-targeting somatostatin (SOM) interneurons are critical for a visually induced, context-dependent gamma rhythm in the visual cortex (V1).",
        "experimental_conditions": "in vivo SOM optogenetic manipulation"
      },
      {
        "n": 0,
        "doi": "10.1523/jneurosci.0261-20.2020",
        "value": "both PV and SST disruption decreases slow gamma power",
        "method": "optogenetics + LFP in slice",
        "metric": "Effect of PV/SST disruption on hippocampal gamma",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "abstract_only",
        "n_definition": "mouse hippocampal slices",
        "scope_region": "hippocampus CA3",
        "study_system": "mouse hippocampal CA3 ex vivo",
        "taxonomic_level": "broad category",
        "scope_population": "PV and SST interneurons",
        "value_source_sentence": "Disrupting either PV+ or SST+ interneuron activity, via either photoinhibition or photoexcitation, led to a decrease in the power of cholinergically induced slow gamma oscillations.",
        "experimental_conditions": "optogenetic disruption of PV or SST"
      },
      {
        "n": 0,
        "doi": "10.7554/eLife.28569",
        "value": "SOM-dependent, PV-independent (30 Hz narrow band)",
        "method": "optogenetics + LFP in slice",
        "metric": "PV vs SOM dependence of V1 gamma",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "mouse brain slices",
        "scope_region": "primary visual cortex",
        "study_system": "mouse visual cortex brain slices",
        "taxonomic_level": "broad category",
        "scope_population": "SOM and PV interneurons",
        "value_source_sentence": "The network oscillations generated here depend on SOM neuron but not parvalbumin (PV) neuron activity.",
        "experimental_conditions": "optogenetic patterned illumination in acute slices"
      }
    ],
    "comparison_id": "pv-vs-som-gamma-contribution",
    "comparison_name": "PV vs SOM interneuron contribution to gamma oscillations across brain regions",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "The relative contribution of PV vs SOM interneurons to gamma depends critically on brain region, gamma subtype, and experimental preparation - challenging a simple PV-centric model",
    "homogeneity_check": {
      "caveats": [
        "Studies compare different brain regions (neocortex, V1, CA3)",
        "Mix of in vivo and in vitro preparations",
        "Different gamma subtypes (broad-band vs narrow 30 Hz vs slow gamma)"
      ],
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  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json",
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  "source_refs": [
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    "paper:paper-676bfe401c07",
    "paper:paper-d5a7d63abc9a",
    "paper:paper-de315a7499ba"
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  "section_title": "Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony",
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