{
"id": "unitary_EPSP_distribution_mouse_cortex",
"type": "unitary EPSP amplitude distribution",
"description": "Distributions of unitary EPSP amplitudes between mouse cortical pyramidal pairs across studies (log-normal/heavy-tailed signature; rare strong, many weak).",
"audit_issues": [
{
"dimension": "metric_definition",
"description": "Sources report different statistics of uEPSP distributions: per-layer-pair amplitudes (Lefort 2009), in vivo L2 CV ≈ 0.74 with median <0.5 mV (Jouhanneau 2015), 'distributions' (Seeman 2018 — DOI mismatch), 'log-normal efficacy across cell types' (Optomapping, missing DOI), and L2/3 mouse-S1 unitary amplitudes (Avermann 2012). They do not all yield a comparable scalar.",
"entries_affected": [
"10.1038/nature14182",
"10.1016/j.neuron.2008.12.020",
"10.1016/j.celrep.2015.11.011",
"10.7554/elife.26839",
"10.1152/jn.00917.2011",
""
]
},
{
"dimension": "scope_region",
"description": "Lefort/Avermann use S1, others V1; the comparison mixes sensory areas without uniform layer-pair scope.",
"entries_affected": [
"10.1038/nature14182",
"10.1016/j.neuron.2008.12.020",
"10.1016/j.celrep.2015.11.011",
"10.7554/elife.26839",
"10.1152/jn.00917.2011"
]
}
],
"audit_verdict": "SPLIT",
"section_targets": [
"section_03"
],
"comparable_sources": [
{
"doi": "10.1016/j.neuron.2008.12.020",
"pmid": "19186171",
"what": "Lefort 2009 — uEPSP by layer pair"
},
{
"doi": "10.1016/j.celrep.2015.11.011",
"pmid": "26670044",
"what": "Jouhanneau 2015 — in vivo L2 uEPSP (CV ≈ 0.74, most <0.5 mV)"
},
{
"doi": "10.7554/elife.26839",
"pmid": "30256194",
"what": "Seeman 2018 — multipatch V1 uEPSP distributions"
},
{
"doi": "",
"pmid": "39872485",
"what": "Optomapping V1 — log-normal efficacy across cell types"
},
{
"doi": "10.1152/jn.00917.2011",
"pmid": "22402650",
"what": "Avermann 2012 — L2/3 mouse S1 unitary amplitudes"
}
],
"primary_source_doi": "10.1038/nature14182",
"primary_source_pmid": "25652823",
"notes_for_extraction": "Extract uEPSP amplitude histograms (and fit parameters) from Cossell 2015 V1, Lefort 2009 S1 by-layer, Jouhanneau 2015 in vivo L2, Seeman 2018 multipatch V1, optomapping (PMID 39872485). Plot on log axis to assess log-normal consistency vs deviations.",
"claim_source_sentence": "Excitatory connection amplitudes between pairs of cortical neurons vary over two orders of magnitude, comprising only very few strong connections among many weaker ones.",
"audit_fabrication_flag": "Label 'Seeman 2018' on DOI 10.7554/elife.26839 does not match DOI authors (Kondo et al. 2017). One entry ('Optomapping V1') has no DOI.",
"mandatory_caption_caveats": [
"uEPSP distributions are reported with different statistics (CV, median, mean, log-normal-fit parameters) across studies — values cannot be plotted on a common amplitude axis without re-extraction from the source data.",
"Mixed cortical areas (mouse V1 vs. S1 barrel column).",
"Verify the 'Seeman 2018' source identifier (DOI 10.7554/elife.26839 maps to Kondo et al. 2017).",
"Phase 7 writer: SPLIT verdict — implement as: Restrict to studies that report at least the median and IQR of unitary EPSP amplitudes in a single, defined layer-pair (e.g., L2/3→L2/3 in V1). Drop entries without a DOI."
]
}