Version history

{
  "kind": "infographic",
  "prompt": "3. Paired-recording evidence in mouse — connection probabilities and synaptic strengths between pyramidal cells within a column, layer-by-layer (Lefort, Petersen, Adesnik, Feldmeyer, Markram-style work in mouse) figure 2",
  "provider": "other",
  "raw_fields": {
    "id": "unitary_EPSP_distribution_mouse_cortex",
    "type": "unitary EPSP amplitude distribution",
    "description": "Distributions of unitary EPSP amplitudes between mouse cortical pyramidal pairs across studies (log-normal/heavy-tailed signature; rare strong, many weak).",
    "audit_issues": [
      {
        "dimension": "metric_definition",
        "description": "Sources report different statistics of uEPSP distributions: per-layer-pair amplitudes (Lefort 2009), in vivo L2 CV ≈ 0.74 with median <0.5 mV (Jouhanneau 2015), 'distributions' (Seeman 2018 — DOI mismatch), 'log-normal efficacy across cell types' (Optomapping, missing DOI), and L2/3 mouse-S1 unitary amplitudes (Avermann 2012). They do not all yield a comparable scalar.",
        "entries_affected": [
          "10.1038/nature14182",
          "10.1016/j.neuron.2008.12.020",
          "10.1016/j.celrep.2015.11.011",
          "10.7554/elife.26839",
          "10.1152/jn.00917.2011",
          ""
        ]
      },
      {
        "dimension": "scope_region",
        "description": "Lefort/Avermann use S1, others V1; the comparison mixes sensory areas without uniform layer-pair scope.",
        "entries_affected": [
          "10.1038/nature14182",
          "10.1016/j.neuron.2008.12.020",
          "10.1016/j.celrep.2015.11.011",
          "10.7554/elife.26839",
          "10.1152/jn.00917.2011"
        ]
      }
    ],
    "audit_verdict": "SPLIT",
    "section_targets": [
      "section_03"
    ],
    "comparable_sources": [
      {
        "doi": "10.1016/j.neuron.2008.12.020",
        "pmid": "19186171",
        "what": "Lefort 2009 — uEPSP by layer pair"
      },
      {
        "doi": "10.1016/j.celrep.2015.11.011",
        "pmid": "26670044",
        "what": "Jouhanneau 2015 — in vivo L2 uEPSP (CV ≈ 0.74, most <0.5 mV)"
      },
      {
        "doi": "10.7554/elife.26839",
        "pmid": "30256194",
        "what": "Seeman 2018 — multipatch V1 uEPSP distributions"
      },
      {
        "doi": "",
        "pmid": "39872485",
        "what": "Optomapping V1 — log-normal efficacy across cell types"
      },
      {
        "doi": "10.1152/jn.00917.2011",
        "pmid": "22402650",
        "what": "Avermann 2012 — L2/3 mouse S1 unitary amplitudes"
      }
    ],
    "primary_source_doi": "10.1038/nature14182",
    "primary_source_pmid": "25652823",
    "notes_for_extraction": "Extract uEPSP amplitude histograms (and fit parameters) from Cossell 2015 V1, Lefort 2009 S1 by-layer, Jouhanneau 2015 in vivo L2, Seeman 2018 multipatch V1, optomapping (PMID 39872485). Plot on log axis to assess log-normal consistency vs deviations.",
    "claim_source_sentence": "Excitatory connection amplitudes between pairs of cortical neurons vary over two orders of magnitude, comprising only very few strong connections among many weaker ones.",
    "audit_fabrication_flag": "Label 'Seeman 2018' on DOI 10.7554/elife.26839 does not match DOI authors (Kondo et al. 2017). One entry ('Optomapping V1') has no DOI.",
    "mandatory_caption_caveats": [
      "uEPSP distributions are reported with different statistics (CV, median, mean, log-normal-fit parameters) across studies — values cannot be plotted on a common amplitude axis without re-extraction from the source data.",
      "Mixed cortical areas (mouse V1 vs. S1 barrel column).",
      "Verify the 'Seeman 2018' source identifier (DOI 10.7554/elife.26839 maps to Kondo et al. 2017).",
      "Phase 7 writer: SPLIT verdict — implement as: Restrict to studies that report at least the median and IQR of unitary EPSP amplitudes in a single, defined layer-pair (e.g., L2/3→L2/3 in V1). Drop entries without a DOI."
    ]
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_03_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewrecurrence-03-paired-recording",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-03-paired-recording",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [],
  "section_title": "3. Paired-recording evidence in mouse — connection probabilities and synaptic strengths between pyramidal cells within a column, layer-by-layer (Lefort, Petersen, Adesnik, Feldmeyer, Markram-style work in mouse)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_03_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}