Timeline of ventral-to-dorsal striatal engagement during drug taking progression

{
  "title": "Timeline of ventral-to-dorsal striatal engagement during drug taking progression",
  "papers": [
    {
      "doi": "10.1101/2025.10.07.680788",
      "value": "dorsal striatum engagement during chronic drug use",
      "method": "behavioral pharmacology",
      "cite_key": "Veros2025",
      "study_system": "rat",
      "value_source_sentence": "Specifically, habitual behavior is mediated by increased synaptic strength in D2 MSNs in dorsolateral striatum (DLS), suggesting similar cell-type-specific synaptic changes may underlie the developmen"
    },
    {
      "doi": "10.3390/ijms26157356",
      "value": "dorsal striatum engagement during chronic drug use",
      "method": "behavioral pharmacology",
      "cite_key": "Wabreha2025",
      "study_system": "rat",
      "value_source_sentence": "The diagnosis of opioid use disorder (OUD) is prevalent due to increased prescribing of opioids."
    },
    {
      "doi": "10.1038/s41598-025-11438-4",
      "value": "dorsal striatum engagement during chronic drug use",
      "method": "behavioral pharmacology",
      "cite_key": "Ma2025b",
      "study_system": "rat",
      "value_source_sentence": "Compared with HCs, MADIs at Stage I demonstrated decreased brain activity in three cortical regions and increased brain activity in several subcortical regions, especially bilateral putamen."
    }
  ],
  "x_axis": "Stage of drug exposure (acute, chronic, compulsive)",
  "y_axis": "Relative engagement (ventral vs dorsal striatum)",
  "figure_id": "fig_sec2_dorsal_striatum_shift",
  "n_analyzed": "varies widely",
  "n_definition": "animals or sessions tracked per study",
  "scope_region": "ventral striatum (NAc) and dorsal striatum (DMS, DLS)",
  "comparison_type": "temporal progression comparison",
  "taxonomic_level": "region-level (ventral vs dorsal)",
  "scope_population": "striatal projection neurons",
  "homogeneity_check": "Poor comparability across studies. The ventral-to-dorsal shift framework is supported mainly by dopamine-dependent disconnection studies in rats using cocaine. Evidence for this progression with other drugs (opioids, alcohol) is weaker. The timeline differs substantially between short-access and long-access self-administration models, making cross-study temporal comparisons unreliable."
}

[
  "paper:paper-112a2616bba5",
  "paper:paper-314e667f2e26",
  "paper:paper-bddcfb3c7041"
]

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