Version history

{
  "kind": "infographic",
  "prompt": "Timeline of ventral-to-dorsal striatal engagement during drug taking progression",
  "provider": "other",
  "raw_fields": {
    "title": "Timeline of ventral-to-dorsal striatal engagement during drug taking progression",
    "papers": [
      {
        "doi": "10.1101/2025.10.07.680788",
        "value": "dorsal striatum engagement during chronic drug use",
        "method": "behavioral pharmacology",
        "cite_key": "Veros2025",
        "study_system": "rat",
        "value_source_sentence": "Specifically, habitual behavior is mediated by increased synaptic strength in D2 MSNs in dorsolateral striatum (DLS), suggesting similar cell-type-specific synaptic changes may underlie the developmen"
      },
      {
        "doi": "10.3390/ijms26157356",
        "value": "dorsal striatum engagement during chronic drug use",
        "method": "behavioral pharmacology",
        "cite_key": "Wabreha2025",
        "study_system": "rat",
        "value_source_sentence": "The diagnosis of opioid use disorder (OUD) is prevalent due to increased prescribing of opioids."
      },
      {
        "doi": "10.1038/s41598-025-11438-4",
        "value": "dorsal striatum engagement during chronic drug use",
        "method": "behavioral pharmacology",
        "cite_key": "Ma2025b",
        "study_system": "rat",
        "value_source_sentence": "Compared with HCs, MADIs at Stage I demonstrated decreased brain activity in three cortical regions and increased brain activity in several subcortical regions, especially bilateral putamen."
      }
    ],
    "x_axis": "Stage of drug exposure (acute, chronic, compulsive)",
    "y_axis": "Relative engagement (ventral vs dorsal striatum)",
    "figure_id": "fig_sec2_dorsal_striatum_shift",
    "n_analyzed": "varies widely",
    "n_definition": "animals or sessions tracked per study",
    "scope_region": "ventral striatum (NAc) and dorsal striatum (DMS, DLS)",
    "comparison_type": "temporal progression comparison",
    "taxonomic_level": "region-level (ventral vs dorsal)",
    "scope_population": "striatal projection neurons",
    "homogeneity_check": "Poor comparability across studies. The ventral-to-dorsal shift framework is supported mainly by dopamine-dependent disconnection studies in rats using cocaine. Evidence for this progression with other drugs (opioids, alcohol) is weaker. The timeline differs substantially between short-access and long-access self-administration models, making cross-study temporal comparisons unreliable."
  },
  "section_id": "section_02_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_02_evidence.json",
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    "paper:paper-112a2616bba5",
    "paper:paper-314e667f2e26",
    "paper:paper-bddcfb3c7041"
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  "section_title": "The Canonical Reward Circuit: Anatomy, Cell Types, and Emerging Complexity",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
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  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
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  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}