SST Co-expression with Other Markers Across Species and Brain Regions

{
  "papers": [
    {
      "doi": "10.1002/cne.22229",
      "value": "21.6%",
      "method": "immunohistochemistry",
      "metric": "SOM/CR co-expression percentage",
      "cite_key": "Xu2010",
      "condition": "neocortex, multiple layers",
      "study_system": "mouse",
      "value_source_sentence": "The average overlap of SOM/CR (percentage of SOM+ cells expressing CR) across all examined layers and cortical regions was 21.6%."
    },
    {
      "doi": "10.1002/cne.22229",
      "value": "7.1%",
      "method": "immunohistochemistry",
      "metric": "SOM/NPY co-expression percentage",
      "cite_key": "Xu2010",
      "condition": "neocortex, multiple layers",
      "study_system": "mouse",
      "value_source_sentence": "The average overlap of SOM/NPY across all examined layers and cortical regions was 7.1%."
    },
    {
      "doi": "10.3390/ijms20122952",
      "value": "present in mouse, absent in rat neocortex",
      "method": "immunohistochemistry review",
      "metric": "SOM/calretinin co-expression species difference",
      "cite_key": "Riedemann2019",
      "condition": "neocortex, cross-species",
      "study_system": "mouse vs rat",
      "value_source_sentence": "SOM colocalization with calretinin was reported in the mouse but not in the rat neocortex."
    },
    {
      "doi": "10.1002/dneu.20853",
      "value": "~30%",
      "method": "review of immunohistochemistry + genetics",
      "metric": "SST proportion of GABAergic neurons",
      "cite_key": "Rudy2011",
      "condition": "somatosensory cortex",
      "study_system": "mouse",
      "value_source_sentence": "The SST group, which represents ~30% of GABAergic neurons."
    }
  ],
  "comparison_id": "sst-marker-coexpression-patterns",
  "comparison_name": "SST Co-expression with Other Markers Across Species and Brain Regions",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "SST co-expression patterns with calretinin, calbindin, NPY, and nNOS vary significantly across species and brain regions, demonstrating that SST is not a uniform marker and that co-expression profiles define functionally distinct subtypes.",
  "homogeneity_check": {
    "caveats": [
      "Different antibodies and immunohistochemistry protocols may yield different co-expression rates",
      "Species differences (mouse vs rat) are confounded by regional differences in the studies reviewed",
      "Some data are from reviews summarizing multiple studies with different methodologies"
    ],
    "comparable": false
  },
  "suggested_plot_type": "heatmap"
}

[
  "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9",
  "paper:paper-36ff07041899",
  "paper:paper-f74768c3fc02"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}