Version history

{
  "kind": "infographic",
  "prompt": "SST co-expression patterns with calretinin, calbindin, NPY, and nNOS vary significantly across species and brain regions, demonstrating that SST is not a uniform marker and that co-expression profiles define functionally distinct subtypes.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1002/cne.22229",
        "value": "21.6%",
        "method": "immunohistochemistry",
        "metric": "SOM/CR co-expression percentage",
        "cite_key": "Xu2010",
        "condition": "neocortex, multiple layers",
        "study_system": "mouse",
        "value_source_sentence": "The average overlap of SOM/CR (percentage of SOM+ cells expressing CR) across all examined layers and cortical regions was 21.6%."
      },
      {
        "doi": "10.1002/cne.22229",
        "value": "7.1%",
        "method": "immunohistochemistry",
        "metric": "SOM/NPY co-expression percentage",
        "cite_key": "Xu2010",
        "condition": "neocortex, multiple layers",
        "study_system": "mouse",
        "value_source_sentence": "The average overlap of SOM/NPY across all examined layers and cortical regions was 7.1%."
      },
      {
        "doi": "10.3390/ijms20122952",
        "value": "present in mouse, absent in rat neocortex",
        "method": "immunohistochemistry review",
        "metric": "SOM/calretinin co-expression species difference",
        "cite_key": "Riedemann2019",
        "condition": "neocortex, cross-species",
        "study_system": "mouse vs rat",
        "value_source_sentence": "SOM colocalization with calretinin was reported in the mouse but not in the rat neocortex."
      },
      {
        "doi": "10.1002/dneu.20853",
        "value": "~30%",
        "method": "review of immunohistochemistry + genetics",
        "metric": "SST proportion of GABAergic neurons",
        "cite_key": "Rudy2011",
        "condition": "somatosensory cortex",
        "study_system": "mouse",
        "value_source_sentence": "The SST group, which represents ~30% of GABAergic neurons."
      }
    ],
    "comparison_id": "sst-marker-coexpression-patterns",
    "comparison_name": "SST Co-expression with Other Markers Across Species and Brain Regions",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "SST co-expression patterns with calretinin, calbindin, NPY, and nNOS vary significantly across species and brain regions, demonstrating that SST is not a uniform marker and that co-expression profiles define functionally distinct subtypes.",
    "homogeneity_check": {
      "caveats": [
        "Different antibodies and immunohistochemistry protocols may yield different co-expression rates",
        "Species differences (mouse vs rat) are confounded by regional differences in the studies reviewed",
        "Some data are from reviews summarizing multiple studies with different methodologies"
      ],
      "comparable": false
    },
    "suggested_plot_type": "heatmap"
  },
  "section_id": "section_02_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_02_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-02",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-02",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9",
    "paper:paper-36ff07041899",
    "paper:paper-f74768c3fc02"
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_02_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}