PV Interneuron Postnatal Maturation Timeline Across Species/Conditions

{
  "papers": [
    {
      "n": 0,
      "doi": "10.18240/ijo.2025.12.03",
      "value": "postnatal week 7",
      "method": "immunohistochemistry for PV and WFA",
      "metric": "Postnatal age when PV+/PNN+ expression reaches adult levels",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "animals per age group",
      "scope_region": "visual cortex",
      "study_system": "rat, visual cortex",
      "taxonomic_level": "single cell type (PV+)",
      "scope_population": "PV-positive interneurons",
      "value_source_sentence": "The number of PV-positive neurons and PNNs-surrounded PV neurons in the rat visual cortex increases postnatally and reaches adult levels by postnatal week 7.",
      "experimental_conditions": "normal development"
    },
    {
      "n": 0,
      "doi": "10.1016/j.celrep.2012.10.003",
      "value": "SATB1 required postnatally for PV expression",
      "method": "immunohistochemistry, fate mapping",
      "metric": "Transcription factor requirement for PV maturation",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "animals per genotype",
      "scope_region": "whole cortex",
      "study_system": "mouse, cortex",
      "taxonomic_level": "single cell type (PV+)",
      "scope_population": "PV-positive interneurons",
      "value_source_sentence": "Satb1 mutant cortex showed a dramatic decrease in the number of cells expressing PV, while the number of SST-expressing cells was largely unaffected.",
      "experimental_conditions": "Satb1 conditional knockout"
    },
    {
      "n": 0,
      "doi": "10.1177/10507256251390868",
      "value": "thyroid hormones act as timer for PV maturation",
      "method": "thyroid hormone signaling perturbation",
      "metric": "Endocrine regulation of PV maturation timing",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "animals",
      "scope_region": "neocortex",
      "study_system": "mouse, neocortex",
      "taxonomic_level": "single cell type (PV+)",
      "scope_population": "PV-positive interneurons",
      "value_source_sentence": "Thyroid Hormones Act as a Timer for the Postnatal Maturation of Parvalbumin Neurons in Mouse Neocortex.",
      "experimental_conditions": "thyroid hormone manipulation"
    }
  ],
  "comparison_id": "pv-maturation-timeline-across-species",
  "comparison_name": "PV Interneuron Postnatal Maturation Timeline Across Species/Conditions",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "Multiple regulatory mechanisms (intrinsic TFs like SATB1, environmental signals like PNN formation, endocrine factors like thyroid hormones) converge to regulate PV maturation timeline, with different temporal windows for each",
  "homogeneity_check": {
    "caveats": [
      "Visual cortex (rat) vs whole cortex (mouse) vs neocortex (mouse) - different brain regions",
      "Rat vs mouse species difference in maturation timeline",
      "Different metrics: absolute timing vs TF requirement vs endocrine regulation"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "timeline"
}

[
  "paper:paper-17a4dfba1c18",
  "paper:paper-5ff194ad9010",
  "paper:paper-a41ff0022587"
]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}