Version history

{
  "kind": "infographic",
  "prompt": "Multiple regulatory mechanisms (intrinsic TFs like SATB1, environmental signals like PNN formation, endocrine factors like thyroid hormones) converge to regulate PV maturation timeline, with different temporal windows for each",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.18240/ijo.2025.12.03",
        "value": "postnatal week 7",
        "method": "immunohistochemistry for PV and WFA",
        "metric": "Postnatal age when PV+/PNN+ expression reaches adult levels",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "animals per age group",
        "scope_region": "visual cortex",
        "study_system": "rat, visual cortex",
        "taxonomic_level": "single cell type (PV+)",
        "scope_population": "PV-positive interneurons",
        "value_source_sentence": "The number of PV-positive neurons and PNNs-surrounded PV neurons in the rat visual cortex increases postnatally and reaches adult levels by postnatal week 7.",
        "experimental_conditions": "normal development"
      },
      {
        "n": 0,
        "doi": "10.1016/j.celrep.2012.10.003",
        "value": "SATB1 required postnatally for PV expression",
        "method": "immunohistochemistry, fate mapping",
        "metric": "Transcription factor requirement for PV maturation",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "animals per genotype",
        "scope_region": "whole cortex",
        "study_system": "mouse, cortex",
        "taxonomic_level": "single cell type (PV+)",
        "scope_population": "PV-positive interneurons",
        "value_source_sentence": "Satb1 mutant cortex showed a dramatic decrease in the number of cells expressing PV, while the number of SST-expressing cells was largely unaffected.",
        "experimental_conditions": "Satb1 conditional knockout"
      },
      {
        "n": 0,
        "doi": "10.1177/10507256251390868",
        "value": "thyroid hormones act as timer for PV maturation",
        "method": "thyroid hormone signaling perturbation",
        "metric": "Endocrine regulation of PV maturation timing",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "animals",
        "scope_region": "neocortex",
        "study_system": "mouse, neocortex",
        "taxonomic_level": "single cell type (PV+)",
        "scope_population": "PV-positive interneurons",
        "value_source_sentence": "Thyroid Hormones Act as a Timer for the Postnatal Maturation of Parvalbumin Neurons in Mouse Neocortex.",
        "experimental_conditions": "thyroid hormone manipulation"
      }
    ],
    "comparison_id": "pv-maturation-timeline-across-species",
    "comparison_name": "PV Interneuron Postnatal Maturation Timeline Across Species/Conditions",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Multiple regulatory mechanisms (intrinsic TFs like SATB1, environmental signals like PNN formation, endocrine factors like thyroid hormones) converge to regulate PV maturation timeline, with different temporal windows for each",
    "homogeneity_check": {
      "caveats": [
        "Visual cortex (rat) vs whole cortex (mouse) vs neocortex (mouse) - different brain regions",
        "Rat vs mouse species difference in maturation timeline",
        "Different metrics: absolute timing vs TF requirement vs endocrine regulation"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "timeline"
  },
  "section_id": "section_03_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-03",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-03",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-17a4dfba1c18",
    "paper:paper-5ff194ad9010",
    "paper:paper-a41ff0022587"
  ],
  "section_title": "Developmental Origins: MGE Lineage, Specification, and Migration",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}