Timeline of neural changes from acquisition to chronic use

{
  "papers": [
    {
      "doi": "10.1186/s13041-024-01094-6",
      "value": "significant change",
      "method": "longitudinal recording",
      "cite_key": "Uchida2024",
      "value_source_sentence": "Electrophysiological recordings from brain slices prepared from a mouse model of neuropathic pain revealed that rheobase and firing threshold were significantly decreased in the chronic pain group compared with the sham-operated control group."
    }
  ],
  "x_axis": "Stage of drug exposure (days/weeks)",
  "y_axis": "Normalized signal change from baseline",
  "n_analyzed": "varies by study",
  "n_definition": "animals with longitudinal recordings",
  "scope_region": "mesolimbic circuit (VTA, NAc)",
  "source_cluster": 6,
  "comparison_name": "Timeline of neural changes from acquisition to chronic use",
  "comparison_type": "temporal comparison",
  "taxonomic_level": "circuit level",
  "scope_population": "dopamine neurons and target cells",
  "homogeneity_check": "Drug type, dose, schedule, and recording method all differ. Some track population signals, others track single neurons. Direct comparison of timelines is only valid within-drug."
}

[
  "paper:paper-d6bf007de4b2"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}