Version history

{
  "kind": "infographic",
  "prompt": "Timeline of neural changes from acquisition to chronic use",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1186/s13041-024-01094-6",
        "value": "significant change",
        "method": "longitudinal recording",
        "cite_key": "Uchida2024",
        "value_source_sentence": "Electrophysiological recordings from brain slices prepared from a mouse model of neuropathic pain revealed that rheobase and firing threshold were significantly decreased in the chronic pain group compared with the sham-operated control group."
      }
    ],
    "x_axis": "Stage of drug exposure (days/weeks)",
    "y_axis": "Normalized signal change from baseline",
    "n_analyzed": "varies by study",
    "n_definition": "animals with longitudinal recordings",
    "scope_region": "mesolimbic circuit (VTA, NAc)",
    "source_cluster": 6,
    "comparison_name": "Timeline of neural changes from acquisition to chronic use",
    "comparison_type": "temporal comparison",
    "taxonomic_level": "circuit level",
    "scope_population": "dopamine neurons and target cells",
    "homogeneity_check": "Drug type, dose, schedule, and recording method all differ. Some track population signals, others track single neurons. Direct comparison of timelines is only valid within-drug."
  },
  "section_id": "section_12_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "target_ref": "wiki_page:computationalreviewaddiction-12",
  "review_repo": "ComputationalReviewAddiction",
  "section_ref": "wiki_page:computationalreviewaddiction-12",
  "source_path": "evidence/section_12_evidence.json",
  "source_refs": [
    "paper:paper-d6bf007de4b2"
  ],
  "section_title": "Synthesis: An Evidence Scorecard for Addiction Neuroscience",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}