{
"papers": [
{
"doi": "10.3390/ph18121816",
"value": "93 fmol",
"species": "see abstract",
"receptor": "see abstract",
"value_source_sentence": "Saturation binding assays revealed a B<sub>max</sub> = 93 fmol/mg and a K<sub>D</sub> = 0.1 nM, supporting the imageability of Na<sub>V</sub>1.8 in the brain using this tracer."
},
{
"doi": "10.3389/fnins.2024.1380009",
"value": "2.39 fmol",
"species": "see abstract",
"receptor": "see abstract",
"value_source_sentence": "The <i>K<sub>d</sub></i> (0.34 ± 0.22 nM) and B<sub>max</sub> (38.91 ± 2.39 fmol/mg) values of [<sup>125</sup>I]HY-3-24 were determined."
},
{
"doi": "10.1016/j.ejphar.2021.174556",
"value": "22.89 pmol",
"species": "see abstract",
"receptor": "see abstract",
"value_source_sentence": "Using human VAChT-rich cell membrane extracts, a saturated binding curve was obtained for [<sup>3</sup>H]VAT with K<sub>d</sub> = 6.5 nM and B<sub>max</sub> = 22.89 pmol/mg protein."
}
],
"figure_id": "fig_sec10_receptor_density_species",
"n_analyzed": "varies by study, typically 3-10 per species",
"description": "Cross-species comparison of neurotransmitter receptor densities (fmol/mg) measured by autoradiography in cortical regions. Compares available data from rat, macaque, and human cortex.",
"n_definition": "number of brain samples/specimens per species",
"scope_region": "cortex (prefrontal and temporal regions primarily)",
"comparison_type": "Receptor binding density across species",
"taxonomic_level": "species (rat, macaque, human)",
"scope_population": "adult healthy brain tissue",
"homogeneity_check": "CAUTION: Studies use different antibodies, radioligands, tissue preparation methods, and brain regions. Direct numerical comparison across studies requires careful normalization. Receptor subtypes measured differ across studies. Age and post-mortem interval vary."
}