Version history

{
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  "prompt": "The Species Translation Problem: From Mouse Circuits to Human Therapeutics figure 1",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.3390/ph18121816",
        "value": "93 fmol",
        "species": "see abstract",
        "receptor": "see abstract",
        "value_source_sentence": "Saturation binding assays revealed a B<sub>max</sub> = 93 fmol/mg and a K<sub>D</sub> = 0.1 nM, supporting the imageability of Na<sub>V</sub>1.8 in the brain using this tracer."
      },
      {
        "doi": "10.3389/fnins.2024.1380009",
        "value": "2.39 fmol",
        "species": "see abstract",
        "receptor": "see abstract",
        "value_source_sentence": "The <i>K<sub>d</sub></i> (0.34 ± 0.22 nM) and B<sub>max</sub> (38.91 ± 2.39 fmol/mg) values of [<sup>125</sup>I]HY-3-24 were determined."
      },
      {
        "doi": "10.1016/j.ejphar.2021.174556",
        "value": "22.89 pmol",
        "species": "see abstract",
        "receptor": "see abstract",
        "value_source_sentence": "Using human VAChT-rich cell membrane extracts, a saturated binding curve was obtained for [<sup>3</sup>H]VAT with K<sub>d</sub> = 6.5 nM and B<sub>max</sub> = 22.89 pmol/mg protein."
      }
    ],
    "figure_id": "fig_sec10_receptor_density_species",
    "n_analyzed": "varies by study, typically 3-10 per species",
    "description": "Cross-species comparison of neurotransmitter receptor densities (fmol/mg) measured by autoradiography in cortical regions. Compares available data from rat, macaque, and human cortex.",
    "n_definition": "number of brain samples/specimens per species",
    "scope_region": "cortex (prefrontal and temporal regions primarily)",
    "comparison_type": "Receptor binding density across species",
    "taxonomic_level": "species (rat, macaque, human)",
    "scope_population": "adult healthy brain tissue",
    "homogeneity_check": "CAUTION: Studies use different antibodies, radioligands, tissue preparation methods, and brain regions. Direct numerical comparison across studies requires careful normalization. Receptor subtypes measured differ across studies. Age and post-mortem interval vary."
  },
  "section_id": "section_10_evidence",
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  "source_refs": [
    "paper:paper-333a42aeeb12",
    "paper:paper-857a2a591c7c",
    "paper:paper-8665c0c35689"
  ],
  "section_title": "The Species Translation Problem: From Mouse Circuits to Human Therapeutics",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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