Neurotransmitter receptor density across brain regions from PET atlas studies

{
  "title": "Neurotransmitter receptor density across brain regions from PET atlas studies",
  "papers": [
    {
      "n": 1200,
      "doi": "10.1038/s41593-022-01186-3",
      "unit": "PET binding potential",
      "value": "atlas of 19 receptors across 9 neurotransmitter systems",
      "method": "PET",
      "region": "whole brain",
      "receptor": "Multi-receptor (19 types)",
      "value_source_sentence": "Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems."
    },
    {
      "n": 210,
      "doi": "10.1523/jneurosci.2830-16.2016",
      "unit": "PET binding + picomoles/mL",
      "value": "high correlation between PET binding and autoradiography protein levels",
      "method": "PET + autoradiography",
      "region": "whole brain",
      "receptor": "5-HT system (5-HT1A, 5-HT1B, 5-HT2A, 5-HT4, 5-HTT)",
      "value_source_sentence": "Comparison of the regional PET binding measures with postmortem human brain autoradiography outcomes showed a high correlation for the five 5-HT targets"
    },
    {
      "n": null,
      "doi": "10.2967/jnumed.120.246967",
      "unit": "PET binding potential",
      "value": "high in cortex and hippocampus, moderate in striatum, low in thalamus and cerebellum",
      "method": "PET",
      "region": "cortex > hippocampus > striatum > thalamus > cerebellum",
      "receptor": "M1 muscarinic",
      "value_source_sentence": "This was a first-in-human study of the PET radiotracer 11C-LSN3172176 for the muscarinic acetylcholine receptor subtype 1 (M1)"
    },
    {
      "n": null,
      "doi": "10.1016/s0028-3908(03)00050-9",
      "unit": "PET ligand uptake",
      "value": "greatly decreased uptake in M2 KO but not M1/M3/M4 KO",
      "method": "PET + knockout validation",
      "region": "regional brain",
      "receptor": "M2 muscarinic",
      "value_source_sentence": "Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice."
    },
    {
      "n": null,
      "doi": "10.1186/s13550-020-00650-0",
      "unit": "SPECT binding potential",
      "value": "quantifiable striatal and extrastriatal D2/3",
      "method": "SPECT",
      "region": "striatal + extrastriatal",
      "receptor": "D2/D3 dopamine",
      "value_source_sentence": "In vivo absolute quantification of striatal and extrastriatal D2/3 receptors"
    }
  ],
  "x_axis": "Brain region",
  "y_axis": "Relative receptor density (normalized)",
  "n_analyzed": "varies by study: 1200, 210, not reported",
  "n_definition": "number of subjects scanned",
  "scope_region": "whole brain, multiple regions",
  "comparison_id": "fig_sec3_receptor_density_regions",
  "comparison_type": "cross-regional receptor density",
  "taxonomic_level": "receptor subtype",
  "scope_population": "healthy humans and rodent models",
  "homogeneity_check": "Studies use different imaging modalities (PET, SPECT, autoradiography) and species (human, mouse). Hansen atlas provides normalized cross-receptor comparison; individual studies provide receptor-specific regional detail. Direct numerical comparison across studies requires normalization to common scale. Caution: PET binding potential is not directly comparable to autoradiographic density measurements."
}

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  "paper:paper-8c66fed0864e",
  "paper:paper-99cce26a9088",
  "paper:paper-b68f802078ae",
  "paper:paper-e1ce9847cb04"
]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
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