Version history

{
  "kind": "infographic",
  "prompt": "Neurotransmitter receptor density across brain regions from PET atlas studies",
  "provider": "other",
  "raw_fields": {
    "title": "Neurotransmitter receptor density across brain regions from PET atlas studies",
    "papers": [
      {
        "n": 1200,
        "doi": "10.1038/s41593-022-01186-3",
        "unit": "PET binding potential",
        "value": "atlas of 19 receptors across 9 neurotransmitter systems",
        "method": "PET",
        "region": "whole brain",
        "receptor": "Multi-receptor (19 types)",
        "value_source_sentence": "Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems."
      },
      {
        "n": 210,
        "doi": "10.1523/jneurosci.2830-16.2016",
        "unit": "PET binding + picomoles/mL",
        "value": "high correlation between PET binding and autoradiography protein levels",
        "method": "PET + autoradiography",
        "region": "whole brain",
        "receptor": "5-HT system (5-HT1A, 5-HT1B, 5-HT2A, 5-HT4, 5-HTT)",
        "value_source_sentence": "Comparison of the regional PET binding measures with postmortem human brain autoradiography outcomes showed a high correlation for the five 5-HT targets"
      },
      {
        "n": null,
        "doi": "10.2967/jnumed.120.246967",
        "unit": "PET binding potential",
        "value": "high in cortex and hippocampus, moderate in striatum, low in thalamus and cerebellum",
        "method": "PET",
        "region": "cortex > hippocampus > striatum > thalamus > cerebellum",
        "receptor": "M1 muscarinic",
        "value_source_sentence": "This was a first-in-human study of the PET radiotracer 11C-LSN3172176 for the muscarinic acetylcholine receptor subtype 1 (M1)"
      },
      {
        "n": null,
        "doi": "10.1016/s0028-3908(03)00050-9",
        "unit": "PET ligand uptake",
        "value": "greatly decreased uptake in M2 KO but not M1/M3/M4 KO",
        "method": "PET + knockout validation",
        "region": "regional brain",
        "receptor": "M2 muscarinic",
        "value_source_sentence": "Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice."
      },
      {
        "n": null,
        "doi": "10.1186/s13550-020-00650-0",
        "unit": "SPECT binding potential",
        "value": "quantifiable striatal and extrastriatal D2/3",
        "method": "SPECT",
        "region": "striatal + extrastriatal",
        "receptor": "D2/D3 dopamine",
        "value_source_sentence": "In vivo absolute quantification of striatal and extrastriatal D2/3 receptors"
      }
    ],
    "x_axis": "Brain region",
    "y_axis": "Relative receptor density (normalized)",
    "n_analyzed": "varies by study: 1200, 210, not reported",
    "n_definition": "number of subjects scanned",
    "scope_region": "whole brain, multiple regions",
    "comparison_id": "fig_sec3_receptor_density_regions",
    "comparison_type": "cross-regional receptor density",
    "taxonomic_level": "receptor subtype",
    "scope_population": "healthy humans and rodent models",
    "homogeneity_check": "Studies use different imaging modalities (PET, SPECT, autoradiography) and species (human, mouse). Hansen atlas provides normalized cross-receptor comparison; individual studies provide receptor-specific regional detail. Direct numerical comparison across studies requires normalization to common scale. Caution: PET binding potential is not directly comparable to autoradiographic density measurements."
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  "section_title": "Receptor Pharmacology and Region-Specific Expression",
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