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{ "kind": "infographic", "prompt": "Proportion of Animals Showing Compulsive-Like Drug Seeking Across Paradigms", "provider": "other", "raw_fields": { "title": "Proportion of Animals Showing Compulsive-Like Drug Seeking Across Paradigms", "papers": [ { "doi": "10.1037/bne0000590", "value": "(PsycInfo Database Record (c) 2024 APA, all rights reserved)", "cite_key": "Felix2024", "value_source_sentence": "(PsycInfo Database Record (c) 2024 APA, all rights reserved)" }, { "doi": "10.1038/s41380-024-02455-2", "value": "At the end of the punishment phase, rats underwent 15 days of forced abstinence at the end of which they were re-introduced to the SA paradigm followe", "cite_key": "Daiwile2024", "value_source_sentence": "At the end of the punishment phase, rats underwent 15 days of forced abstinence at the end of which they were re-introduced to the SA paradigm followed by SA plus contingent shocks" }, { "doi": "10.1016/j.biopsych.2017.03.004", "value": "In experiment 3, cluster analysis of the aggression-related measures identified a subset of \"addicted\" mice (∼19%) that exhibited intense operant-rein", "cite_key": "Golden2017", "value_source_sentence": "In experiment 3, cluster analysis of the aggression-related measures identified a subset of \"addicted\" mice (∼19%) that exhibited intense operant-reinforced attack behavior, decreased likelihood to select an alternative reinforcer over aggression, heightened relapse vulnerability and progressive rat" }, { "doi": "10.1038/s41386-024-01940-0", "value": "We trained Long-Evans outbred rats (n = 96) to self-administer 20% ethanol, and then introduced response-contingent footshock", "cite_key": "McDonald2024", "value_source_sentence": "We trained Long-Evans outbred rats (n = 96) to self-administer 20% ethanol, and then introduced response-contingent footshock" }, { "doi": "10.1038/s41398-026-03825-w", "value": "Only a minority of alcohol users develop alcohol use disorder (AUD), and the extent to which vulnerability to this condition depends on sex remains in", "cite_key": "Borruto2026", "value_source_sentence": "Only a minority of alcohol users develop alcohol use disorder (AUD), and the extent to which vulnerability to this condition depends on sex remains insufficiently explored in preclinical research" }, { "doi": "10.1016/j.neuropharm.2020.107974", "value": "Male LEW and F344 rats aged six weeks were exposed to increasing Δ<sup>9</sup>-tetrahydrocannabinol (THC) doses, twice a day for 3 days (2, 4, 8 mg/kg", "cite_key": "Lecca2020", "value_source_sentence": "Male LEW and F344 rats aged six weeks were exposed to increasing Δ<sup>9</sup>-tetrahydrocannabinol (THC) doses, twice a day for 3 days (2, 4, 8 mg/kg, i" }, { "doi": "10.1101/2024.07.08.602268", "value": "This uniformity contrasts sharply with the significantly different ways humans use heroin and cocaine, which are characterized by highly individualize", "cite_key": "DOttavio2024", "value_source_sentence": "This uniformity contrasts sharply with the significantly different ways humans use heroin and cocaine, which are characterized by highly individualized drug use behaviors" } ], "n_analyzed": "Animals classified as 'compulsive' by study-specific criteria", "description": "Cross-study comparison of the fraction of animals meeting criteria for compulsive drug taking", "n_definition": "Total animals with drug access across the full experimental protocol", "scope_region": "N/A - behavioral classification", "comparison_id": "fig3_compulsivity_rates", "source_cluster": 5, "taxonomic_level": "Species-specific (rat)", "scope_population": "Outbred adult rats", "homogeneity_check": { "caveats": [ "Criteria for 'compulsive-like' behavior vary across labs (Deroche-Gamonet 3-criteria vs punishment persistence vs escalation + punishment)", "Different drugs studied (cocaine vs methamphetamine vs opioids)", "Access duration varies", "Punishment parameters (shock intensity, contingency) differ", "Some studies classify animals post-hoc, others use prospective criteria" ], "comparable": false } }, "section_id": "section_12_evidence", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json", "target_ref": "wiki_page:computationalreviewaddiction-12", "review_repo": "ComputationalReviewAddiction", "section_ref": "wiki_page:computationalreviewaddiction-12", "source_path": "evidence/section_12_evidence.json", "source_refs": [ "paper:paper-54f52ebf247b", "paper:paper-7256eaea4989", "paper:paper-7dbeabd31158", "paper:paper-b01cba40bff8", "paper:paper-be4617eb64b9", "paper:paper-be4df6a9c802", "paper:paper-fdaabdae0e47" ], "section_title": "Synthesis: An Evidence Scorecard for Addiction Neuroscience", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction" }, "generation_status": "complete", "review_bundle_ref": "analysis_bundle:ab-d95cfb705572", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json", "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction" }