NAc MSN subtype proportions and co-expression

{
  "title": "NAc MSN subtype proportions and co-expression",
  "papers": [
    {
      "doi": "10.3390/cells15010032",
      "value": "~90% MSNs express D1 or D2",
      "method": "review of ISH/IHC studies",
      "cite_key": "TabordaBejarano2025",
      "study_system": "mouse/rat",
      "value_source_sentence": "Within the NAcore, approximately 90% of neurons are medium spiny neurons (MSNs) that express either dopamine receptor 1 (D1-MSNs) or dopamine receptor 2 (D2-MSNs)."
    },
    {
      "doi": "10.3390/ijms262110526",
      "value": "90-95% MSNs with D1R or D2R",
      "method": "review",
      "cite_key": "Essmat2025",
      "study_system": "rodent",
      "value_source_sentence": "In the NAc, two GABAergic medium spiny neuron (MSN) populations are distinguished, comprising 90–95% of all NAc neurons."
    },
    {
      "doi": "10.3390/ijms262110526",
      "value": "D1R-MSN vs D2R-MSN classification",
      "method": "molecular characterization",
      "cite_key": "Essmat2025",
      "study_system": "rodent",
      "value_source_sentence": "MSNs express either DA D1 receptors (D1R) or D2 receptors (D2R), and are classified as D1R-MSNs or D2R-MSNs."
    }
  ],
  "x_axis": "MSN subtype (D1, D2, co-expressing)",
  "y_axis": "Percentage of NAc MSNs",
  "figure_id": "fig_sec2_d1d2_composition",
  "n_analyzed": "varies; typically hundreds to thousands per study",
  "n_definition": "total neurons counted per histological section",
  "scope_region": "nucleus accumbens (core and shell)",
  "comparison_type": "cross-study quantitative comparison",
  "taxonomic_level": "receptor subtype expression",
  "scope_population": "medium spiny neurons",
  "homogeneity_check": "Mostly comparable. The 90-95% MSN proportion is well replicated across studies and species. However, the strict D1/D2 binary is complicated by evidence of D1/D2 co-expression in a subset (~5-17% depending on region and method), which varies between NAc core and shell and between dorsal and ventral striatum."
}

[
  "paper:paper-120b28547e78",
  "paper:paper-9da047bf979d"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}