Version history

{
  "kind": "infographic",
  "prompt": "NAc MSN subtype proportions and co-expression",
  "provider": "other",
  "raw_fields": {
    "title": "NAc MSN subtype proportions and co-expression",
    "papers": [
      {
        "doi": "10.3390/cells15010032",
        "value": "~90% MSNs express D1 or D2",
        "method": "review of ISH/IHC studies",
        "cite_key": "TabordaBejarano2025",
        "study_system": "mouse/rat",
        "value_source_sentence": "Within the NAcore, approximately 90% of neurons are medium spiny neurons (MSNs) that express either dopamine receptor 1 (D1-MSNs) or dopamine receptor 2 (D2-MSNs)."
      },
      {
        "doi": "10.3390/ijms262110526",
        "value": "90-95% MSNs with D1R or D2R",
        "method": "review",
        "cite_key": "Essmat2025",
        "study_system": "rodent",
        "value_source_sentence": "In the NAc, two GABAergic medium spiny neuron (MSN) populations are distinguished, comprising 90–95% of all NAc neurons."
      },
      {
        "doi": "10.3390/ijms262110526",
        "value": "D1R-MSN vs D2R-MSN classification",
        "method": "molecular characterization",
        "cite_key": "Essmat2025",
        "study_system": "rodent",
        "value_source_sentence": "MSNs express either DA D1 receptors (D1R) or D2 receptors (D2R), and are classified as D1R-MSNs or D2R-MSNs."
      }
    ],
    "x_axis": "MSN subtype (D1, D2, co-expressing)",
    "y_axis": "Percentage of NAc MSNs",
    "figure_id": "fig_sec2_d1d2_composition",
    "n_analyzed": "varies; typically hundreds to thousands per study",
    "n_definition": "total neurons counted per histological section",
    "scope_region": "nucleus accumbens (core and shell)",
    "comparison_type": "cross-study quantitative comparison",
    "taxonomic_level": "receptor subtype expression",
    "scope_population": "medium spiny neurons",
    "homogeneity_check": "Mostly comparable. The 90-95% MSN proportion is well replicated across studies and species. However, the strict D1/D2 binary is complicated by evidence of D1/D2 co-expression in a subset (~5-17% depending on region and method), which varies between NAc core and shell and between dorsal and ventral striatum."
  },
  "section_id": "section_02_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_02_evidence.json",
  "target_ref": "wiki_page:computationalreviewaddiction-02",
  "review_repo": "ComputationalReviewAddiction",
  "section_ref": "wiki_page:computationalreviewaddiction-02",
  "source_path": "evidence/section_02_evidence.json",
  "source_refs": [
    "paper:paper-120b28547e78",
    "paper:paper-9da047bf979d"
  ],
  "section_title": "The Canonical Reward Circuit: Anatomy, Cell Types, and Emerging Complexity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_02_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}