{
"metric": "Response gain change (% or fold)",
"papers": [
{
"n": 1,
"doi": "10.1152/jn.00587.2019",
"value": "300%",
"cite_key": "Cooke2020",
"study_system": "mouse",
"value_source_sentence": "In keeping with the hypothesis that shunting inhibition contributes to gain control, the input conductance of V1 neurons has been found to increase by up to 300% from baseline during stimulation with high-contrast gratings ( Anderson et al."
},
{
"n": null,
"doi": "10.7554/elife.53552",
"value": "20 Hz",
"cite_key": "Azimi2020",
"study_system": "mouse",
"value_source_sentence": "( c ) MUA, showing activation following onset of photostimulation (16 s of 20 Hz, blue light pulses of 25 ms pulse width)."
},
{
"n": null,
"doi": "10.1523/jneurosci.3836-15.2016",
"value": "60%",
"cite_key": "Connelly2016",
"study_system": "rat",
"value_source_sentence": "Indeed, TC neurons are also innervated by local GABAergic interneurons and thalamic reticular nucleus (TRN) neurons, which themselves receive direct cortical input, meaning that 60%–70% of synapses on TC neurons are influenced directly or indirectly by cortical activity ( Wolfart et al., 2005 )."
},
{
"n": 103,
"doi": "10.1038/s41467-024-51861-1",
"value": "48%",
"cite_key": "Barzan2024",
"study_system": "mouse",
"value_source_sentence": "2a , dark orange trace, “direct effect”, +48% cf."
},
{
"n": null,
"doi": "10.3389/fneur.2014.00206",
"value": "25%",
"cite_key": "Auerbach2014",
"study_system": "mouse",
"value_source_sentence": "The rate-level function of VCN neurons displayed enhancement on the order of 25% after noise-exposures ( 64 ), whereas enhancement of rate-level functions in neurons of IC were on the order of 40–50% ( 69 – 71 )."
},
{
"n": null,
"doi": "10.1002/phy2.67",
"value": "95%",
"cite_key": "Pouille2013",
"study_system": "mouse",
"value_source_sentence": "Methods Animal experiments Acute slices preparation Acute slices (400 μm) of hippocampus were prepared from 3- to 4-week-old Wistar rats and incubated for 45–60 min in an interface chamber at 35°C in artificial cerebrospinal fluid (ACSF) equilibrated with 95% O 2 and 5% CO 2 , containing (in m"
}
],
"section": "4.4",
"n_analyzed": "varies by study",
"n_definition": "varies: neurons recorded, animals, sessions",
"scope_region": "primary visual cortex (V1)",
"comparison_name": "PV vs SST interneuron activation: gain control effects on pyramidal cell responses",
"taxonomic_level": "N/A",
"scope_population": "pyramidal neurons responding to oriented gratings",
"homogeneity_check": "CAUTION: Key confounds include optogenetic stimulation intensity, expression level of opsins, behavioral state (anesthetized vs awake), and whether activation was step vs ramp. The divisive-vs-subtractive distinction may be an artifact of stimulation regime rather than an intrinsic property."
}