Version history

{
  "kind": "infographic",
  "prompt": "PV vs SST interneuron activation: gain control effects on pyramidal cell responses",
  "provider": "other",
  "raw_fields": {
    "metric": "Response gain change (% or fold)",
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      {
        "n": 1,
        "doi": "10.1152/jn.00587.2019",
        "value": "300%",
        "cite_key": "Cooke2020",
        "study_system": "mouse",
        "value_source_sentence": "In keeping with the hypothesis that shunting inhibition contributes to gain control, the input conductance of V1 neurons has been found to increase by up to 300% from baseline during stimulation with high-contrast gratings ( Anderson et al."
      },
      {
        "n": null,
        "doi": "10.7554/elife.53552",
        "value": "20 Hz",
        "cite_key": "Azimi2020",
        "study_system": "mouse",
        "value_source_sentence": "( c ) MUA, showing activation following onset of photostimulation (16 s of 20 Hz, blue light pulses of 25 ms pulse width)."
      },
      {
        "n": null,
        "doi": "10.1523/jneurosci.3836-15.2016",
        "value": "60%",
        "cite_key": "Connelly2016",
        "study_system": "rat",
        "value_source_sentence": "Indeed, TC neurons are also innervated by local GABAergic interneurons and thalamic reticular nucleus (TRN) neurons, which themselves receive direct cortical input, meaning that 60%–70% of synapses on TC neurons are influenced directly or indirectly by cortical activity ( Wolfart et al., 2005 )."
      },
      {
        "n": 103,
        "doi": "10.1038/s41467-024-51861-1",
        "value": "48%",
        "cite_key": "Barzan2024",
        "study_system": "mouse",
        "value_source_sentence": "2a , dark orange trace, “direct effect”, +48% cf."
      },
      {
        "n": null,
        "doi": "10.3389/fneur.2014.00206",
        "value": "25%",
        "cite_key": "Auerbach2014",
        "study_system": "mouse",
        "value_source_sentence": "The rate-level function of VCN neurons displayed enhancement on the order of 25% after noise-exposures ( 64 ), whereas enhancement of rate-level functions in neurons of IC were on the order of 40–50% ( 69 – 71 )."
      },
      {
        "n": null,
        "doi": "10.1002/phy2.67",
        "value": "95%",
        "cite_key": "Pouille2013",
        "study_system": "mouse",
        "value_source_sentence": "Methods   Animal experiments   Acute slices preparation  Acute slices (400 μm) of hippocampus were prepared from 3- to 4-week-old Wistar rats and incubated for 45–60 min in an interface chamber at 35°C in artificial cerebrospinal fluid (ACSF) equilibrated with 95% O 2  and 5% CO 2 , containing (in m"
      }
    ],
    "section": "4.4",
    "n_analyzed": "varies by study",
    "n_definition": "varies: neurons recorded, animals, sessions",
    "scope_region": "primary visual cortex (V1)",
    "comparison_name": "PV vs SST interneuron activation: gain control effects on pyramidal cell responses",
    "taxonomic_level": "N/A",
    "scope_population": "pyramidal neurons responding to oriented gratings",
    "homogeneity_check": "CAUTION: Key confounds include optogenetic stimulation intensity, expression level of opsins, behavioral state (anesthetized vs awake), and whether activation was step vs ramp. The divisive-vs-subtractive distinction may be an artifact of stimulation regime rather than an intrinsic property."
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    "paper:paper-600ec3c00517",
    "paper:paper-68e3e7eb6c50",
    "paper:paper-d6cade3c4824"
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  "section_title": "PV Interneuron Function",
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