Details

kind
infographic
prompt
Drug-Specific Mechanisms: Challenging the Final Common Pathway figure 3
provider
other
section_id
section_05_evidence
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_05_evidence.json
target_ref
wiki_page:computationalreviewaddiction-05
review_repo
ComputationalReviewAddiction
section_ref
wiki_page:computationalreviewaddiction-05
source_path
evidence/section_05_evidence.json
section_title
Drug-Specific Mechanisms: Challenging the Final Common Pathway
generation_status
complete
review_bundle_ref
analysis_bundle:ab-d95cfb705572
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_05_evidence.json
commit_sha
43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction
Raw fields (3)
raw_fields
{
  "papers": [
    {
      "n": null,
      "doi": "10.1038/s41586-025-09427-8",
      "value": null,
      "method": "various",
      "metric": "reward circuit engagement",
      "cite_key": "Gomez2025",
      "n_analyzed": null,
      "text_access": "fulltext",
      "n_definition": "animals or subjects",
      "scope_region": "mesolimbic circuit",
      "study_system": "rats",
      "taxonomic_level": "drug class",
      "scope_population": "drug-exposed",
      "value_source_sentence": null,
      "experimental_conditions": "Expression of an excitatory cocaine-gated channel in the rat lateral habenula, a brain region that i"
    },
    {
      "n": 6,
      "doi": "10.3389/fphar.2026.1757023",
      "value": "1%",
      "method": "various",
      "metric": "reward circuit engagement",
      "cite_key": "deOliveira2026",
      "n_analyzed": 6,
      "text_access": "fulltext",
      "n_definition": "animals or subjects",
      "scope_region": "mesolimbic circuit",
      "study_system": "mice",
      "taxonomic_level": "drug class",
      "scope_population": "drug-exposed",
      "value_source_sentence": "2.2 Drugs The animals were treated with FK506 (Tacrolimus; LC Laboratory, United States), which was diluted in a solution of 1% DMSO, 5% Tween 80, and sterile saline, at a dose of 5 mg/kg, administered via subcutaneous (s.c.) injection 80 min before each behavioral test.",
      "experimental_conditions": "Dendritic spine density was evaluated in the dentate gyrus and nucleus accumbens.<h4>Results</h4>In "
    },
    {
      "n": null,
      "doi": "10.7554/elife.100085",
      "value": "25%",
      "method": "various",
      "metric": "reward circuit engagement",
      "cite_key": "Oriol2025",
      "n_analyzed": null,
      "text_access": "fulltext",
      "n_definition": "animals or subjects",
      "scope_region": "mesolimbic circuit",
      "study_system": "rats",
      "taxonomic_level": "drug class",
      "scope_population": "drug-exposed",
      "value_source_sentence": "Glutamate neurons are also prevalent in VTA and overlap with other populations such that ~25% of VTA glutamate neurons co-express a DA marker and ~25% express a GABA marker ( Conrad et al., 2024 ; Ma et al., 2023 ; Phillips et al., 2022 ).",
      "experimental_conditions": "Challenging previous assumptions, we found that VTA neurons genetically defined by expression of par"
    },
    {
      "n": null,
      "doi": "10.1038/s42003-026-09705-9",
      "value": "3.8%",
      "method": "various",
      "metric": "reward circuit engagement",
      "cite_key": "Zhang2026b",
      "n_analyzed": null,
      "text_access": "fulltext",
      "n_definition": "animals or subjects",
      "scope_region": "mesolimbic circuit",
      "study_system": "rats",
      "taxonomic_level": "drug class",
      "scope_population": "drug-exposed",
      "value_source_sentence": "Cannabis and depression Approximately 3.8% of the global population has used cannabis, primarily due to cannabinoids, which are classified as endocannabinoids, phytocannabinoids, and synthetic cannabinoids.",
      "experimental_conditions": "Emerging evidence indicates that chronic exposure to addictive substances can induce or exacerbate d"
    }
  ],
  "comparison_id": "fig_sec5_convergent_vs_divergent",
  "comparison_type": "evidence_scorecard",
  "homogeneity_check": {
    "caveats": [
      "Evidence strength varies by drug class — some have decades of research, others are newer",
      "DA-dependent vs DA-independent evidence is asymmetric across drugs",
      "Self-administration paradigms differ across drug classes"
    ],
    "comparable": true,
    "n_definition": "studies reporting DA measurement",
    "scope_region": "nucleus accumbens and related regions",
    "taxonomic_level": "drug class",
    "scope_population": "drug-exposed rodents or humans"
  },
  "suggested_plot_type": "heatmap"
}
source_refs
[
  "paper:paper-a77b6ea3644a",
  "paper:paper-b41cb09f704f",
  "paper:paper-b7c11c558bcb",
  "paper:paper-d32f13914759"
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}

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