Version history

{
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  "prompt": "Drug-Specific Mechanisms: Challenging the Final Common Pathway figure 3",
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        "experimental_conditions": "Expression of an excitatory cocaine-gated channel in the rat lateral habenula, a brain region that i"
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        "cite_key": "deOliveira2026",
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        "value_source_sentence": "2.2 Drugs The animals were treated with FK506 (Tacrolimus; LC Laboratory, United States), which was diluted in a solution of 1% DMSO, 5% Tween 80, and sterile saline, at a dose of 5 mg/kg, administered via subcutaneous (s.c.) injection 80 min before each behavioral test.",
        "experimental_conditions": "Dendritic spine density was evaluated in the dentate gyrus and nucleus accumbens.<h4>Results</h4>In "
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        "value_source_sentence": "Glutamate neurons are also prevalent in VTA and overlap with other populations such that ~25% of VTA glutamate neurons co-express a DA marker and ~25% express a GABA marker ( Conrad et al., 2024 ; Ma et al., 2023 ; Phillips et al., 2022 ).",
        "experimental_conditions": "Challenging previous assumptions, we found that VTA neurons genetically defined by expression of par"
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        "doi": "10.1038/s42003-026-09705-9",
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        "value_source_sentence": "Cannabis and depression Approximately 3.8% of the global population has used cannabis, primarily due to cannabinoids, which are classified as endocannabinoids, phytocannabinoids, and synthetic cannabinoids.",
        "experimental_conditions": "Emerging evidence indicates that chronic exposure to addictive substances can induce or exacerbate d"
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    "homogeneity_check": {
      "caveats": [
        "Evidence strength varies by drug class — some have decades of research, others are newer",
        "DA-dependent vs DA-independent evidence is asymmetric across drugs",
        "Self-administration paradigms differ across drug classes"
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      "comparable": true,
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      "scope_region": "nucleus accumbens and related regions",
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  },
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    "paper:paper-b41cb09f704f",
    "paper:paper-b7c11c558bcb",
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  "section_title": "Drug-Specific Mechanisms: Challenging the Final Common Pathway",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
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