PV interneuron vulnerability across brain regions in disease models

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1523/JNEUROSCI.0425-20.2020",
      "value": "50% reduction",
      "method": "whole-cell patch clamp",
      "metric": "PV basket cell excitatory drive reduction",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "PV basket cells recorded",
      "scope_region": "hippocampus CA1",
      "study_system": "5xFAD mouse hippocampal CA1",
      "taxonomic_level": "fine type",
      "scope_population": "PV basket cells",
      "value_source_sentence": "Excitatory synaptic drive to PVBCs was selectively reduced by 50%, resulting in decreased E/I ratio.",
      "experimental_conditions": "3-month 5xFAD vs controls"
    },
    {
      "n": 0,
      "doi": "10.1186/s13229-025-00699-5",
      "value": "inhibitory deficit",
      "method": "electrophysiology, functional connectivity",
      "metric": "Inhibitory deficit in amygdala",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "mice per genotype",
      "scope_region": "amygdala",
      "study_system": "PV-Cre Mecp2 cKO mouse amygdala",
      "taxonomic_level": "broad category",
      "scope_population": "all PV interneurons",
      "value_source_sentence": "Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity.",
      "experimental_conditions": "Mecp2 conditional knockout in PV cells"
    },
    {
      "n": 0,
      "doi": "10.4103/nrr.nrr-d-25-00928",
      "value": "decreased density",
      "method": "immunohistochemistry",
      "metric": "PV cell density change in TRN",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "rats per group",
      "scope_region": "thalamic reticular nucleus",
      "study_system": "rat TRN, NVHL schizophrenia model",
      "taxonomic_level": "broad category",
      "scope_population": "all PV-positive cells",
      "value_source_sentence": "We demonstrate a decrease in the density of parvalbumin-positive cells within the thalamic reticular nucleus in the neonatal ventral hippocampus lesion model.",
      "experimental_conditions": "neonatal ventral hippocampus lesion"
    }
  ],
  "comparison_id": "pv-vulnerability-across-brain-regions",
  "comparison_name": "PV interneuron vulnerability across brain regions in disease models",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "PV interneurons show region-specific vulnerability across different disease models, suggesting PV vulnerability is a common disease mechanism but manifests differently by region",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions, disease models, and species - illustrates convergent pattern"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "false",
    "scope_population_uniform": "false"
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-54726517a4fb",
  "paper:paper-cf3a69a4d883",
  "paper:paper-f5596943188f"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}