Version history

{
  "kind": "infographic",
  "prompt": "PV interneurons show region-specific vulnerability across different disease models, suggesting PV vulnerability is a common disease mechanism but manifests differently by region",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1523/JNEUROSCI.0425-20.2020",
        "value": "50% reduction",
        "method": "whole-cell patch clamp",
        "metric": "PV basket cell excitatory drive reduction",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "PV basket cells recorded",
        "scope_region": "hippocampus CA1",
        "study_system": "5xFAD mouse hippocampal CA1",
        "taxonomic_level": "fine type",
        "scope_population": "PV basket cells",
        "value_source_sentence": "Excitatory synaptic drive to PVBCs was selectively reduced by 50%, resulting in decreased E/I ratio.",
        "experimental_conditions": "3-month 5xFAD vs controls"
      },
      {
        "n": 0,
        "doi": "10.1186/s13229-025-00699-5",
        "value": "inhibitory deficit",
        "method": "electrophysiology, functional connectivity",
        "metric": "Inhibitory deficit in amygdala",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "mice per genotype",
        "scope_region": "amygdala",
        "study_system": "PV-Cre Mecp2 cKO mouse amygdala",
        "taxonomic_level": "broad category",
        "scope_population": "all PV interneurons",
        "value_source_sentence": "Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity.",
        "experimental_conditions": "Mecp2 conditional knockout in PV cells"
      },
      {
        "n": 0,
        "doi": "10.4103/nrr.nrr-d-25-00928",
        "value": "decreased density",
        "method": "immunohistochemistry",
        "metric": "PV cell density change in TRN",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "rats per group",
        "scope_region": "thalamic reticular nucleus",
        "study_system": "rat TRN, NVHL schizophrenia model",
        "taxonomic_level": "broad category",
        "scope_population": "all PV-positive cells",
        "value_source_sentence": "We demonstrate a decrease in the density of parvalbumin-positive cells within the thalamic reticular nucleus in the neonatal ventral hippocampus lesion model.",
        "experimental_conditions": "neonatal ventral hippocampus lesion"
      }
    ],
    "comparison_id": "pv-vulnerability-across-brain-regions",
    "comparison_name": "PV interneuron vulnerability across brain regions in disease models",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "PV interneurons show region-specific vulnerability across different disease models, suggesting PV vulnerability is a common disease mechanism but manifests differently by region",
    "homogeneity_check": {
      "caveats": [
        "Different brain regions, disease models, and species - illustrates convergent pattern"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "false",
      "scope_population_uniform": "false"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_09_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-09",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-09",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-54726517a4fb",
    "paper:paper-cf3a69a4d883",
    "paper:paper-f5596943188f"
  ],
  "section_title": "Brain Region and Layer Context: Beyond Primary Sensory Cortex",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}