D1R vs D2R Effects on Prefrontal Decision Coding Dynamics

{
  "title": "D1R vs D2R Effects on Prefrontal Decision Coding Dynamics",
  "papers": [
    {
      "doi": "10.1073/pnas.2600210123",
      "value": "D1R stimulation: suppressed decision-coding strength, reduced temporal generalizability (dynamic regime)",
      "region": "Prefrontal cortex",
      "text_access": "abstract_only",
      "study_system": "non-human primate",
      "value_source_sentence": "D1R stimulation suppressed, whereas D2R stimulation enhanced, the decision-coding strength of individual neurons, effects mirrored at the population level in decoding accuracy."
    },
    {
      "doi": "10.1073/pnas.2600210123",
      "value": "D2R stimulation: enhanced decision-coding strength, increased temporal generalizability (static regime)",
      "region": "Prefrontal cortex",
      "text_access": "abstract_only",
      "study_system": "non-human primate",
      "value_source_sentence": "D2R stimulation increased temporal generalizability of decision selectivity, implying more sustained tuning and a shift toward a more static coding regime."
    }
  ],
  "x_axis": "Receptor manipulation",
  "y_axis": "Decision coding properties",
  "n_analyzed": "2 monkeys",
  "description": "Comparison of how D1 and D2 receptor stimulation in PFC affects decision coding strength and temporal dynamics",
  "figure_type": "bidirectional_comparison",
  "n_definition": "N = monkeys performing number comparison task",
  "scope_region": "Prefrontal cortex, single-neuron recordings",
  "comparison_id": "dopamine_receptor_PFC_coding_effects",
  "taxonomic_level": "single-cell electrophysiology with iontophoresis",
  "scope_population": "Single neurons in PFC of behaving primates",
  "homogeneity_check": "Single study, single task (number comparison), local iontophoretic drug delivery. High internal validity. Caveat: n=2 monkeys, abstract-level task (number comparison) may not generalize to working memory maintenance tasks."
}

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]

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