Version history

{
  "kind": "infographic",
  "prompt": "D1R vs D2R Effects on Prefrontal Decision Coding Dynamics",
  "provider": "other",
  "raw_fields": {
    "title": "D1R vs D2R Effects on Prefrontal Decision Coding Dynamics",
    "papers": [
      {
        "doi": "10.1073/pnas.2600210123",
        "value": "D1R stimulation: suppressed decision-coding strength, reduced temporal generalizability (dynamic regime)",
        "region": "Prefrontal cortex",
        "text_access": "abstract_only",
        "study_system": "non-human primate",
        "value_source_sentence": "D1R stimulation suppressed, whereas D2R stimulation enhanced, the decision-coding strength of individual neurons, effects mirrored at the population level in decoding accuracy."
      },
      {
        "doi": "10.1073/pnas.2600210123",
        "value": "D2R stimulation: enhanced decision-coding strength, increased temporal generalizability (static regime)",
        "region": "Prefrontal cortex",
        "text_access": "abstract_only",
        "study_system": "non-human primate",
        "value_source_sentence": "D2R stimulation increased temporal generalizability of decision selectivity, implying more sustained tuning and a shift toward a more static coding regime."
      }
    ],
    "x_axis": "Receptor manipulation",
    "y_axis": "Decision coding properties",
    "n_analyzed": "2 monkeys",
    "description": "Comparison of how D1 and D2 receptor stimulation in PFC affects decision coding strength and temporal dynamics",
    "figure_type": "bidirectional_comparison",
    "n_definition": "N = monkeys performing number comparison task",
    "scope_region": "Prefrontal cortex, single-neuron recordings",
    "comparison_id": "dopamine_receptor_PFC_coding_effects",
    "taxonomic_level": "single-cell electrophysiology with iontophoresis",
    "scope_population": "Single neurons in PFC of behaving primates",
    "homogeneity_check": "Single study, single task (number comparison), local iontophoretic drug delivery. High internal validity. Caveat: n=2 monkeys, abstract-level task (number comparison) may not generalize to working memory maintenance tasks."
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  "section_title": "Dopamine: From Reward Signal to Brain-Wide Modulator",
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