Perineuronal net density reduction in schizophrenia postmortem studies

{
  "papers": [
    {
      "n": 7,
      "doi": "10.1016/j.schres.2024.07.023",
      "value": "6 of 7",
      "method": "Systematic review",
      "metric": "Studies reporting significant PNN reduction",
      "n_analyzed": 7,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "Case-control postmortem studies",
      "scope_region": "Multiple brain regions",
      "study_system": "Human postmortem brain, schizophrenia",
      "taxonomic_level": "PNN structures (primarily surrounding PV neurons)",
      "scope_population": "All WFA-labeled PNNs",
      "value_source_sentence": "Findings were mostly positive for reduced PNN density in SCZ, with 6 of the 7 studies reporting significant reductions.",
      "experimental_conditions": "Multiple brain regions (DLPFC, amygdala)"
    }
  ],
  "comparison_id": "pnn-density-schizophrenia",
  "comparison_name": "Perineuronal net density reduction in schizophrenia postmortem studies",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "PNN reductions in schizophrenia are consistent (6/7) but the evidence base is small and methodologically heterogeneous.",
  "homogeneity_check": {
    "caveats": [
      "Studies examined different brain regions",
      "Tissue processing methodologies were heterogeneous"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "forest plot"
}

[
  "paper:paper-ae472e8a4809"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}