Version history

{
  "kind": "infographic",
  "prompt": "PNN reductions in schizophrenia are consistent (6/7) but the evidence base is small and methodologically heterogeneous.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 7,
        "doi": "10.1016/j.schres.2024.07.023",
        "value": "6 of 7",
        "method": "Systematic review",
        "metric": "Studies reporting significant PNN reduction",
        "n_analyzed": 7,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "Case-control postmortem studies",
        "scope_region": "Multiple brain regions",
        "study_system": "Human postmortem brain, schizophrenia",
        "taxonomic_level": "PNN structures (primarily surrounding PV neurons)",
        "scope_population": "All WFA-labeled PNNs",
        "value_source_sentence": "Findings were mostly positive for reduced PNN density in SCZ, with 6 of the 7 studies reporting significant reductions.",
        "experimental_conditions": "Multiple brain regions (DLPFC, amygdala)"
      }
    ],
    "comparison_id": "pnn-density-schizophrenia",
    "comparison_name": "Perineuronal net density reduction in schizophrenia postmortem studies",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "PNN reductions in schizophrenia are consistent (6/7) but the evidence base is small and methodologically heterogeneous.",
    "homogeneity_check": {
      "caveats": [
        "Studies examined different brain regions",
        "Tissue processing methodologies were heterogeneous"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_13_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-13",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-13",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-ae472e8a4809"
  ],
  "section_title": "Cross-Cluster Synthesis: What Replicates, What Is Contested, What Is Untested",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}