Differential Properties of Basket Cell vs Axo-Axonic Cell Output Synapses

Basket cells and axo-axonic cells have distinct synaptic output properties despite both being PV-positive. AACs show larger amplitude but these are specifically vulnerable in pathological conditions, while basket cell connections are more robust and reliable.

{
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    {
      "n": 0,
      "doi": "10.1111/j.1460-9568.2010.07292.x",
      "value": "AACs evoked uIPSCs with largest amplitude and longest decay",
      "method": "whole-cell paired recordings from anatomically identified interneurons",
      "metric": "uIPSC amplitude from AACs vs FSBCs",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "paired recordings from identified cell types",
      "scope_region": "CA3 hippocampus",
      "study_system": "mouse CA3 hippocampus",
      "taxonomic_level": "cell subtype",
      "scope_population": "perisomatic interneurons (FSBC, AAC, RSBC)",
      "value_source_sentence": "GABA released from axon endings of AACs evoked uIPSCs with the largest amplitude and with the longest decay measured at room temperature.",
      "experimental_conditions": "paired recordings, room temperature"
    },
    {
      "n": 0,
      "doi": "10.1113/jp286284",
      "value": "PVBCs more reliably evoke uIPSCs than CCKBCs",
      "method": "whole-cell paired recordings",
      "metric": "Reliability of uIPSC evoked by PVBCs vs CCKBCs",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "paired recordings",
      "scope_region": "medial prefrontal cortex",
      "study_system": "mouse mPFC",
      "taxonomic_level": "cell subtype",
      "scope_population": "PV basket cells vs CCK basket cells",
      "value_source_sentence": "unitary inhibitory postsynaptic currents in PNs were more reliably evoked by PVBCs than by CCKBCs, yet the former connections showed profound short-term depression.",
      "experimental_conditions": "in vitro paired recordings"
    },
    {
      "n": 0,
      "doi": "10.1016/j.pneurobio.2023.102542",
      "value": "SE reduced uIPSC amplitude from AACs to granule cells without altering reliability or STD",
      "method": "paired recordings, optogenetics, computational modeling",
      "metric": "AAC synaptic properties before and after SE",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "paired recordings and optogenetic stimulation",
      "scope_region": "dentate gyrus",
      "study_system": "mouse dentate gyrus",
      "taxonomic_level": "cell subtype",
      "scope_population": "axo-axonic cells",
      "value_source_sentence": "SE reduced the amplitude of unitary synaptic inputs from AACs to granule cells without altering reliability, short-term plasticity, or AIS GABA reversal potential.",
      "experimental_conditions": "pilocarpine SE model"
    }
  ],
  "comparison_id": "perisomatic-vs-aac-properties",
  "comparison_name": "Differential Properties of Basket Cell vs Axo-Axonic Cell Output Synapses",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "Basket cells and axo-axonic cells have distinct synaptic output properties despite both being PV-positive. AACs show larger amplitude but these are specifically vulnerable in pathological conditions, while basket cell connections are more robust and reliable.",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions (CA3, mPFC, dentate)",
      "Different cell subtypes compared (AAC vs FSBC vs PVBC)",
      "Different experimental conditions and species ages"
    ],
    "n_definition_uniform": "true",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "false",
    "scope_population_uniform": "false"
  },
  "suggested_plot_type": "forest plot"
}

[
  "paper:paper-428c53661961",
  "paper:paper-4d0daef43dfa",
  "paper:paper-cd913aa53986"
]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
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