Version history

{
  "kind": "infographic",
  "prompt": "Basket cells and axo-axonic cells have distinct synaptic output properties despite both being PV-positive. AACs show larger amplitude but these are specifically vulnerable in pathological conditions, while basket cell connections are more robust and reliable.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1111/j.1460-9568.2010.07292.x",
        "value": "AACs evoked uIPSCs with largest amplitude and longest decay",
        "method": "whole-cell paired recordings from anatomically identified interneurons",
        "metric": "uIPSC amplitude from AACs vs FSBCs",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "paired recordings from identified cell types",
        "scope_region": "CA3 hippocampus",
        "study_system": "mouse CA3 hippocampus",
        "taxonomic_level": "cell subtype",
        "scope_population": "perisomatic interneurons (FSBC, AAC, RSBC)",
        "value_source_sentence": "GABA released from axon endings of AACs evoked uIPSCs with the largest amplitude and with the longest decay measured at room temperature.",
        "experimental_conditions": "paired recordings, room temperature"
      },
      {
        "n": 0,
        "doi": "10.1113/jp286284",
        "value": "PVBCs more reliably evoke uIPSCs than CCKBCs",
        "method": "whole-cell paired recordings",
        "metric": "Reliability of uIPSC evoked by PVBCs vs CCKBCs",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "paired recordings",
        "scope_region": "medial prefrontal cortex",
        "study_system": "mouse mPFC",
        "taxonomic_level": "cell subtype",
        "scope_population": "PV basket cells vs CCK basket cells",
        "value_source_sentence": "unitary inhibitory postsynaptic currents in PNs were more reliably evoked by PVBCs than by CCKBCs, yet the former connections showed profound short-term depression.",
        "experimental_conditions": "in vitro paired recordings"
      },
      {
        "n": 0,
        "doi": "10.1016/j.pneurobio.2023.102542",
        "value": "SE reduced uIPSC amplitude from AACs to granule cells without altering reliability or STD",
        "method": "paired recordings, optogenetics, computational modeling",
        "metric": "AAC synaptic properties before and after SE",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "paired recordings and optogenetic stimulation",
        "scope_region": "dentate gyrus",
        "study_system": "mouse dentate gyrus",
        "taxonomic_level": "cell subtype",
        "scope_population": "axo-axonic cells",
        "value_source_sentence": "SE reduced the amplitude of unitary synaptic inputs from AACs to granule cells without altering reliability, short-term plasticity, or AIS GABA reversal potential.",
        "experimental_conditions": "pilocarpine SE model"
      }
    ],
    "comparison_id": "perisomatic-vs-aac-properties",
    "comparison_name": "Differential Properties of Basket Cell vs Axo-Axonic Cell Output Synapses",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "Basket cells and axo-axonic cells have distinct synaptic output properties despite both being PV-positive. AACs show larger amplitude but these are specifically vulnerable in pathological conditions, while basket cell connections are more robust and reliable.",
    "homogeneity_check": {
      "caveats": [
        "Different brain regions (CA3, mPFC, dentate)",
        "Different cell subtypes compared (AAC vs FSBC vs PVBC)",
        "Different experimental conditions and species ages"
      ],
      "n_definition_uniform": "true",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "false",
      "scope_population_uniform": "false"
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_06_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-06",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-06",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-428c53661961",
    "paper:paper-4d0daef43dfa",
    "paper:paper-cd913aa53986"
  ],
  "section_title": "Synaptic Physiology: Input Specificity, Output Targeting, and Short-Term Dynamics",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}