Vulnerability, Development, and Individual Differences: Why Not Everyone Become…

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      "doi": "10.1523/jneurosci.0406-21.2021",
      "value": "p>2",
      "cite_key": "Christian2021",
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      "value_source_sentence": "In rats, the expression of incubation ultimately depends on Ca<sup>2+</sup>-permeable AMPARs that accumulate in synapses onto medium spiny neurons (MSNs) in the NAc core."
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      "doi": "10.3390/ijms251910529",
      "value": "20%",
      "cite_key": "ElMostafi2024",
      "n_analyzed": null,
      "n_definition": "participants in epidemiological study",
      "scope_region": "general population / clinical",
      "scope_population": "adults with ACE history",
      "value_source_sentence": "Next, a two-bottle free access paradigm was performed over 10 weeks to assess intermittent 20% ethanol voluntary consumption."
    },
    {
      "doi": "10.3389/fpsyg.2025.1735137",
      "value": "26%",
      "cite_key": "Wei2026",
      "n_analyzed": 692,
      "n_definition": "participants in epidemiological study",
      "scope_region": "general population / clinical",
      "scope_population": "adults with ACE history",
      "value_source_sentence": "(2) Social anxiety (indirect effect = 0.042) and depression (indirect effect = 0.019) formed a chain mediation pathway, explaining 26% of the total effect."
    },
    {
      "doi": "10.3389/fpsyt.2026.1635802",
      "value": "5.8%",
      "cite_key": "Ogilvie2026",
      "n_analyzed": 5,
      "n_definition": "participants in epidemiological study",
      "scope_region": "general population / clinical",
      "scope_population": "adults with ACE history",
      "value_source_sentence": "We examined variation across trajectory groups by sex, Indigenous status (non-Indigenous/Indigenous Australians), psychiatric diagnoses associated with hospital admissions, place of residence (metropolitan, regional, remote), and socioeconomic status.<h4>Results</h4>Four distinct trajectories of MHS contacts were identified, including escalating (5.8%), low (64.5%), adolescent limited (14.5%), and childhood peak declining (15.3%) trajectories."
    },
    {
      "doi": "10.1007/s42844-026-00205-7",
      "value": "14.9%",
      "cite_key": "LaCharite2026",
      "n_analyzed": 200,
      "n_definition": "participants in epidemiological study",
      "scope_region": "general population / clinical",
      "scope_population": "adults with ACE history",
      "value_source_sentence": "Of 7,200 participants, 14.9% were arrested by age 26."
    }
  ],
  "n_definition": "study participants",
  "scope_region": "clinical/epidemiological",
  "comparison_type": "dose_response",
  "taxonomic_level": "N/A",
  "scope_population": "adults with retrospective ACE assessment",
  "homogeneity_check": "Studies vary in ACE measurement instruments, addiction outcome definitions, and population demographics. Direct quantitative comparison requires caution."
}

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    "Local review repositories are read-only inputs.",
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