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- Live5/17/2026, 4:35:28 PM
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{ "kind": "infographic", "prompt": "Vulnerability, Development, and Individual Differences: Why Not Everyone Becomes Addicted figure 1", "provider": "other", "raw_fields": { "name": "Adverse childhood experiences and addiction risk: dose-response relationship", "papers": [ { "doi": "10.1523/jneurosci.0406-21.2021", "value": "p>2", "cite_key": "Christian2021", "n_analyzed": null, "n_definition": "participants in epidemiological study", "scope_region": "general population / clinical", "scope_population": "adults with ACE history", "value_source_sentence": "In rats, the expression of incubation ultimately depends on Ca<sup>2+</sup>-permeable AMPARs that accumulate in synapses onto medium spiny neurons (MSNs) in the NAc core." }, { "doi": "10.3390/ijms251910529", "value": "20%", "cite_key": "ElMostafi2024", "n_analyzed": null, "n_definition": "participants in epidemiological study", "scope_region": "general population / clinical", "scope_population": "adults with ACE history", "value_source_sentence": "Next, a two-bottle free access paradigm was performed over 10 weeks to assess intermittent 20% ethanol voluntary consumption." }, { "doi": "10.3389/fpsyg.2025.1735137", "value": "26%", "cite_key": "Wei2026", "n_analyzed": 692, "n_definition": "participants in epidemiological study", "scope_region": "general population / clinical", "scope_population": "adults with ACE history", "value_source_sentence": "(2) Social anxiety (indirect effect = 0.042) and depression (indirect effect = 0.019) formed a chain mediation pathway, explaining 26% of the total effect." }, { "doi": "10.3389/fpsyt.2026.1635802", "value": "5.8%", "cite_key": "Ogilvie2026", "n_analyzed": 5, "n_definition": "participants in epidemiological study", "scope_region": "general population / clinical", "scope_population": "adults with ACE history", "value_source_sentence": "We examined variation across trajectory groups by sex, Indigenous status (non-Indigenous/Indigenous Australians), psychiatric diagnoses associated with hospital admissions, place of residence (metropolitan, regional, remote), and socioeconomic status.<h4>Results</h4>Four distinct trajectories of MHS contacts were identified, including escalating (5.8%), low (64.5%), adolescent limited (14.5%), and childhood peak declining (15.3%) trajectories." }, { "doi": "10.1007/s42844-026-00205-7", "value": "14.9%", "cite_key": "LaCharite2026", "n_analyzed": 200, "n_definition": "participants in epidemiological study", "scope_region": "general population / clinical", "scope_population": "adults with ACE history", "value_source_sentence": "Of 7,200 participants, 14.9% were arrested by age 26." } ], "n_definition": "study participants", "scope_region": "clinical/epidemiological", "comparison_type": "dose_response", "taxonomic_level": "N/A", "scope_population": "adults with retrospective ACE assessment", "homogeneity_check": "Studies vary in ACE measurement instruments, addiction outcome definitions, and population demographics. Direct quantitative comparison requires caution." }, "section_id": "section_10_evidence", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_10_evidence.json", "target_ref": "wiki_page:computationalreviewaddiction-10", "review_repo": "ComputationalReviewAddiction", "section_ref": "wiki_page:computationalreviewaddiction-10", "source_path": "evidence/section_10_evidence.json", "source_refs": [ "paper:paper-2f19c5976732", "paper:paper-446d26193571", "paper:paper-8d6e58e483ad", "paper:paper-a530a5c1d49d", "paper:paper-fd3fbb3f062b" ], "section_title": "Vulnerability, Development, and Individual Differences: Why Not Everyone Becomes Addicted", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction" }, "generation_status": "complete", "review_bundle_ref": "analysis_bundle:ab-d95cfb705572", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_10_evidence.json", "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction" }