{
"axes": {
"x": "presynaptic-postsynaptic layer pair / cell-pair tuning correlation",
"y": "unitary EPSP amplitude (mV) or efficacy"
},
"datasets": [
{
"doi": "10.1016/j.neuron.2008.12.020",
"method": "paired recording across 6 layers",
"system": "mouse C2 barrel column",
"value_summary": "Layer-specific EPSP amplitudes with rare large-amplitude E→E connections in all layers.",
"claim_source_sentence": "In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information processing."
},
{
"doi": "10.1038/nature14182",
"method": "paired recording + 2P functional imaging",
"system": "mouse V1 L2/3",
"value_summary": "L2/3→L2/3 EPSP amplitudes span >2 orders of magnitude; few strong connections between maximally correlated neurons.",
"claim_source_sentence": "Excitatory connection amplitudes between pairs of cortical neurons vary over two orders of magnitude, comprising only very few strong connections among many weaker ones."
},
{
"doi": "10.1093/cercor/bhx094",
"method": "paired recording",
"system": "mouse C2 barrel column",
"value_summary": "Layer-dependent short-term plasticity directions: depression dominant at many layer pairs; L2 presynaptic gives facilitation at 10–30 ms ISI.",
"claim_source_sentence": "We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections."
},
{
"doi": "10.1126/science.abj5861",
"method": "Allen Institute synaptic physiology platform — paired recordings",
"system": "mouse and human cortex multi-patch dataset (mouse portion in scope)",
"value_summary": "Strength and variability are the two main axes of E synapse heterogeneity; subclasses divide along the variability axis.",
"claim_source_sentence": "The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass."
},
{
"doi": "10.1523/JNEUROSCI.0836-14.2015",
"method": "paired patch + retrograde labeling",
"system": "mouse auditory cortex",
"value_summary": "L2/3→L5B unitary EPSC amplitude/latency/rise/decay are identical for corticocollicular vs corticocallosal targets but short-term plasticity differs (no depression vs substantial depression).",
"claim_source_sentence": "In paired recordings between single L2/3 and labeled L5B neurons, the probabilities of connection, amplitude, latency, rise time, and decay time constant of the unitary EPSC were not different for L2/3→corticocollicular and L2/3→corticocallosal connections."
}
],
"audit_issues": [
{
"dimension": "metric_definition",
"description": "Distributions are reported in different quantities (EPSP amplitude, short-term-plasticity ratio, EPSC amplitude/latency/rise/decay; 'strength + variability axes'). No single y-axis encompasses them.",
"entries_affected": [
"10.1016/j.neuron.2008.12.020",
"10.1038/nature14182",
"10.1093/cercor/bhx094",
"10.1126/science.abj5861",
"10.1523/JNEUROSCI.0836-14.2015"
]
},
{
"dimension": "scope_region",
"description": "S1 barrel column (Lefort, Lavzin), V1 L2/3 (Cossell), and auditory cortex L2/3→L5B (Williamson). Mixed sensory cortices.",
"entries_affected": [
"10.1016/j.neuron.2008.12.020",
"10.1038/nature14182",
"10.1093/cercor/bhx094",
"10.1523/JNEUROSCI.0836-14.2015"
]
},
{
"dimension": "scope_population",
"description": "Layer-pair scopes differ: full 6-layer pairs, L2/3→L2/3, L2/3→L5B target-specific. Distribution shapes are not commensurable when pooled.",
"entries_affected": [
"10.1016/j.neuron.2008.12.020",
"10.1038/nature14182",
"10.1523/JNEUROSCI.0836-14.2015"
]
}
],
"audit_verdict": "CAVEAT",
"figure_concept": "Translaminar E→E unitary EPSP amplitude / synaptic strength distributions in mouse cortex",
"interpretation_note": "Numeric EPSP amplitudes are recorded as paper-specific values; the figure compares unitary strength distributions, log-normal shape (Cossell 2015), translaminar L2/3→L5B sub-target equivalence (Joshi 2015), short-term-plasticity direction (Frandolig 2017), and the Allen synaptic physiology axes (Campagnola 2022).",
"mandatory_caption_caveats": [
"Distributions are quantified in different ways (amplitude, short-term-plasticity index, multi-axis decomposition); rows are not directly stackable on a single amplitude axis.",
"Layer-pair scopes differ across rows (whole 6-layer matrix, L2/3→L2/3 only, L2/3→L5B target-specific)."
]
}